Neural Stem Cells for Brain and Spinal Cord Repair

by Zigova, Tanja; Snyder, Evan Y.; Sanberg, Paul R.

• ISBN13: 9781588290038
• ISBN10: 1588290034
• Format: Hardcover
• Copyright: 2002-12-01
• Publisher: Humana Pr Inc

Summary

Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.

Table of Contents

Dedications	v
Preface	vii
Contributors	xv
Part I: Stem Cells for and from the CNS: Their Source and Fundamental Properties
Sources of Cells for CNS Therapy	3	(42)
Melissa K. Carpenter
Mark Mattson
Mahendra S. Rao
Neural Stem Cells and Their Plasticity	45	(24)
Angela Gritti
Angelo Vescovi
Rossella Galli
Identification, Selection, and Use of Adult Human Oligodendrocyte Progenitor Cells	69	(20)
Martha Windrem
Neeta Roy
Marta Nunes
Steven A. Goldman
Generation, Characterization, and Transplantation of Immortalized Human Neural Crest Stem Cells	89	(18)
Eiji Nakagawa
Kozo Hatori
Atsushi Nagai
Hyun B. Choi
Myung A. Lee
Jung H. Bang
Jean Kim
Jae K. Ryu
Akihiko Ozaki
Min C. Lee
Evan Y. Snyder
Seung U. Kim
The Search for Neural Progenitors in Bone Marrow and Umbilical Cord Blood	107	(28)
Shijie Song
Paul Sanberg
Juan Sanchez-Ramos
Part II: In Vitro and / or In Vivo Manipulations of Stem / Progenitor Cells for the CNS
Signal Transduction Pathways That Regulate Neural Stem Cell Division and Differentiation	135	(48)
Luciano Conti
Elena Cattaneo
Neural Stem/Progenitor Cell Clones or ``Neurospheres'': A Model for Understanding Neuromorphogenesis	183	(20)
Dennis A. Steindler
Bjorn Scheffler
Eric D. Laywell
Oleg N. Suslov
Tong Zheng
Thomas Reiniger
Valery G. Kukekov
Neural Stem Cells and Specification of Cell Fates: Biological and Therapeutical Perspectives	203	(26)
Marcel M. Daadi
Manipulation of Neural Precursors In Situ: Potential for Brain Self-Repair	229	(40)
Sanjay S. P. Magavi
Jeffrey D. Macklis
Neural Stem Cells in the Adult Hippocampus	269	(20)
Jasodhara Ray
Daniel A. Peterson
Part III: Stem / Progenitor Cells in Representative Therapeutic Paradigms for The CNS
Global Gene and Cell Replacement Strategies via Stem Cells	289	(44)
Kook In Park
James J. Palacino
Roseanne Taylor
Karen S. Aboody
Barbara A. Tate
Vaclav Ourednik
Jitka Ourednik
Mahesh Lachyankar
Evan Y. Snyder
Neural Stem Cells in and from the Spinal Cord	333	(14)
Yang D. Teng
Mary Katherine C. White
Erin Lavik
Shaoxiang Liu
Mahesh Lachyankar
Kook In Park
Evan Y. Snyder
Stem Cells for Spinal Cord Injury	347	(20)
Paul Lu
Evan Y. Snyder
Mark H. Tuszynski
Spinal Ischemia-Induced Paraplegia: A Potential Therapeutical Role of Spinally Grafted Neural Precursors and Human hNT Neurons	367	(28)
Martin Marsala
Osamu Kakinohana
Tony L. Yaksh
Joho Tokumine
Utilization of Marrow Stromal Cells for Gene Transfer into the CNS	395	(16)
S. Ausim Azizi
Emily J. Schwarz
Darwin Prockop
Guillermo Alexander
Katherine A. Mortati
Barbara Krynska
Preclinical Basis for Use of NT2N Cells in Neural Transplantation Therapy	411	(20)
Cesario V. Borlongan
Paul R. Sanberg
Index	431