Neural Transplantation in Neurodegenerative Disease Current Status and New Directions

by Chadwick, Derek J.; Goode, Jamie A.

• ISBN13: 9780471492467
• ISBN10: 0471492469
• Edition: 1st
• Format: Hardcover
• Copyright: 2000-12-19
• Publisher: WILEY

Summary

The field of neural transplantation is at a crucial stage, with important clinical trials on transplantation in patients with Parkinson's disease nearing completion and novel, alternative approaches to fetal transplantation being developed.This timely book brings together leading neuroscientists, clinicians, and cell and developmental biologists to discuss the use of neural transplants in neurodegenerative disorders, such as Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis and spinal cord injury. There is also extensive coverage of the potential alternatives to freshly derived fetal tissue as the source of transplants, for example xenografts, encapsulated cells and immortalized stem cells. With authoritative contributions and lively discussion sections, this book presents much new and exciting work in this field and identifies promising new research directions.

Author Biography

Derek J. Chadwick and Jamie A. Goode are editors for Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions and other scientific titles.

Table of Contents

Symposium on Neural transplantation and neurodegenerative disease: current status and new directions, held at the Novartis Foundation, London, 12--14 October 1999
Editors:
Derek J. Chadwick
Jamie A. Goode
This symposium is based on a proposal made by Jeffrey Gray and Stephen Dunnett, and is dedicated to the memory of C. David Marsden
Introduction	1	(6)
Jeffrey A. Gray
Cell replacement strategies for neurodegenerative disorders	7	(14)
Anders Bjorklund
Discussion	16	(5)
Functional analysis of fronto--striatal reconstruction by striatal grafts	21	(32)
Stephen B. Dunnett
Discussion	41	(12)
Functional reconstruction of the hippocampus: fetal versus conditionally immortal neuroepithelial stem cell grafts	53	(17)
H. Hodges
P. Sowinski
D. Virley
A. Nelson
T. R. Kershaw
W. P. Watson
T. Veizovic
S. Patel
A. Mora
T. Rashid
S. J. French
A. Chadwick
J. A. Gray
J. D. Sinden
Discussion	65	(5)
Gene transfer for neuroprotection in animal models of Parkinson's disease and amyotrophic lateral sclerosis	70	(24)
Martha C. Bohn
Bronwen Connor
Dorothy A. Kozlowski
M. Hasan Mohajeri
Discussion	89	(5)
Repair of corticospinal axons by transplantation of olfactory ensheathing cells	94	(16)
Geoff Raisman
Discussion	97	(13)
Neural transplantation in Parkinson's disease	110	(19)
Olle Lindvall
Discussion	123	(6)
Transplantation of human fetal striatal tissue in Huntington's disease: rationale for clinical studies	129	(19)
Thomas B. Freeman
Robert A. Hauser
Alison E. Willing
Tanja Zigova
Paul R. Sanberg
Samuel Saporta
Discussion	139	(9)
General discussion I Prospects for fetal transplants	145	(3)
Neurotransplantation in neurodegenerative disease: a survey of relevant issues in developmental neurobiology	148	(18)
Jack Price
Dafe Uwangho
Scott Peters
Diane Galloway
Karen Mellodew
Discussion	157	(9)
Molecular and cellular mechanisms in immune rejection of intracerebral neural transplants	166	(18)
Thomas Brevig
Erik Bo Pedersen
Bente Finsen
Discussion	177	(7)
Porcine neural xenografts: what are the issues?	184	(18)
Roger A. Barker
Discussion	196	(6)
Gene transfer techniques for the delivery of GDNF in Parkinson's disease	202	(18)
Jean-Luc Ridet
Nicole Deglon
Patrick Aebischer
Discussion	215	(5)
Neurogenesis in the adult hippocampus	220	(22)
Gerd Kempermann
Fred H. Gage
Discussion	235	(7)
Neural stem cells are uniquely suited for cell replacement and gene therapy in the CNS	242	(28)
Vaclav Ourednik
Jitka Ourednik
Kook I. Park
Y.D. Teng
Karen A. Aboody
Kurtis I. Auguste
Rosanne M. Taylor
Barbara A. Tate
Evan Y. Snyder
Discussion	262	(8)
Functional repair with neural stem cells	270	(19)
John D. Sinden
Paul Stroemer
Gregory Grigoryan
Sara Patel
Sarah J. French
Helen Hodges
Discussion	283	(6)
Remyelinating the demyelinated CNS	289	(26)
W. F. Blakemore
P. M. Smith
R. J. M. Franklin
Discussion	298	(17)
General discussion II The ES cell approach	302	(5)
Final discussion The future for fetal grafts	307	(2)
Stem cell strategies	309	(6)
Index of contributors	315	(2)
Subject index	317