The Neurobiology of Central Nervous System Trauma

by Salzman, Steven K.; Faden, Alan I.

• ISBN13: 9780195072303
• ISBN10: 0195072308
• Format: Hardcover
• Copyright: 1994-03-31
• Publisher: Oxford University Press

Summary

This book serves as a reference text in the field of experimental traumatology. Chapters are written by the recognized leaders in each area. The first section covers methodological considerations, including discussion of in vitro and in vivo models; metabolic and hemodynamic factors; anatomical and electrophysiological correlates; and behavioral evaluation. The second section discusses pathophysiological factors including ischemia, ionic changes, immune-inflammatory responses, neurotransmitter/neuromodulatory alterations, effects of lipid metabolism, astroglial responses and molecular mechanisms. The final section reviews treatments including experimental pharmacology, growth factors, regeneration, transplantation and clinical treatment. This book is invaluable to researchers as well as clinicians involved in head or spinal cord injury.

Table of Contents

Methodological Considerations

Experimental Models

In Vivo Models of Experimental

Brain and Spinal Cord Trauma

Anesthetic Management

Models of Neurotrauma Ex Vivo

Intraoperative and Acute Functional Monitors

Electrophysiological Approaches to Mechanisms of Central

Nervous System Trauma

Review of Experimental Methods for StudyingSpinal or Cerebral Blood Flow

The Measurement of Metabolic Changes After Central NervousSystem Trauma

Chronic and Postmortem Measures of Outcome

Behavioral Analyses in Experimental Spinal Cord Trauma

Behavioral Assessment of Outcome Following Experimental HeadInjury

Anatomical Assessment of Spinal Cord Injury

The Pathobiology of Traumatic BrainInjury

Pathophysiological Mechanisms

Wise Young and Shlomi Constantini: Ionic and Water Shifts in Injured CentralNervous Tissues

Lipid Hydrolysis and Free RadicalFormation in Central Nervous System Trauma

Platelet-Activating Factor

Kinins and Related Inflammatory Mediators in CentralNervous System Injury

The Consequences of Inflammation after Injury to the CentralNervous System

Endogenous Opioid Peptides andTraumatic Central Nervous System Injury

Excitotoxicity and Central NervousSystem Trauma

The Role of Neural and Vascular Serotonin in SecondaryCentral Nervous System Trauma

Astrocytic Responses toCentral Nervous System Trauma

Ischemia as a Secondary Neural Injury

Genomic Consequences ofTraumatic Brain Injury

Experimental Treatments

Experimental Pharmacology

Neurotrophic Factors, Growth Factors, and Central NervousSystem Trauma

Reorganization of Neuronal Circuitry Following Central

Nervous System Trauma: Naturally Occurring Processes and Opportunities for

Therapeutic Intervention

Neural Cell Grafting: Anatomical and Functional

Repair of the Spinal Cord

Clinical Issues

Clinical Treatment: Spinal Cord Injury

Clinical Treatment: Head Injury

Clinical Implications of Recent Advances in Neurotrauma

Research

Future Directions

Neurotrauma: Future Directions

Index

Table of Contents provided by Publisher. All Rights Reserved.