The Neurobiology of Cocaine Addiction: From Bench to Bedside

by Joseph; Herman

• ISBN13: 9780789000316
• ISBN10: 0789000318
• Edition: 1st
• Format: Hardcover
• Copyright: 1997-03-18
• Publisher: Routledge

Summary

With the use of crack on the rise in American cities, there is more need than ever to understand the biological, environmental, and social factors behind cocaine addiction, as well as the pharmacological properties of cocaine that make it such an addictive drug. The Neurobiology of Cocaine Addiction helps clinicians and researchers analyze research findings and their relevance to the clinical treatment of cocaine dependency. To do this, it looks at the whole spectrum of cocaine use, from trends in cocaine-involved deaths, hospital emergencies, arrests, and treatment admissions to the specific impact the drug has on brain function. The book reports on important findings from positron emission tomography (PET) and a "binge" pattern cocaine administration mode. This will enable you to improve your understanding of how cocaine alters the pleasure/reward system of the brain and creates new instinctual needs that displace the inherent instinctual needs of hunger and sex. By reading The Neurobiology of Cocaine Addiction, you will sharpen your knowledge of the basic actions of cocaine, the factors related to daily cocaine use, the neurobiological basis of addictive diseases, and drug-induced alterations in normal physiology. You will also learn about: the coexistence of cocaine and heroin addiction cocaine's disruption of the endogenous opioid system QEEG and how it can play a potentially useful role in drug development and planning hypotheses of sensitization in the pathophysiology of cocaine dependence factors that predict daily cocaine use among patients in a methadone maintenance program abnormalities in brain function that persist for up to six months after last cocaine use patterns of cocaine use the importance of prospective data analysis and the limitations of a self-selective study group Clinicians, researchers, psychiatrists, and other professionals in chemical dependency and narcotics rehabilitation will turn the last page of The Neurobiology of Cocaine Addiction with a better understanding of cocaine's addictive qualities and the characteristics of the individuals who become addicted to it. You will see what headway has been made in research at some of the nation's top laboratories, but you will also see what remains to be done. Hopefully, you will find where you can make a contribution either at the practical level, the research level, or both.

Table of Contents

EDITORIAL: Basic Science, Epidemiology, Clinical Practice, and Philanthropy	xiii
Herman Joseph
Barry Stimmel
Cocaine Trends and Other Drug Trends in New York City, 1986-1994	1	(12)
Blanche Frank
John Galea
Daily Cocaine Use Patterns: Effects of Contextual and Psychological Variables	13	(26)
Michael Palij
Andrew Rosenblum
Stephen Magura
Leonard Handelsman
Barry Stimmel
Neaurometric QEEG Studies of Crack Cocaine Dependence and Treatment Outcome	39	(16)
Leslie S. Prichep
Kenneth Alper
Sharon C. Kowalik
Mitchell Rosenthal
Cocaine Addiction: Hypothesis Derived from Imaging Studies with PET	55	(18)
Nora D. Volkow
Yu-Shin Ding
Joanna S. Fowler
Gene-Jack Wang
Cocaine, Dopamine and the Endogenous Opioid System	73	(24)
Mary Jeanne Kreek
Pattern of Cocaine Use in Methadone-Maintained Individuals Applying for Research Studies	97	(10)
Frances Rudnick Levin
Richard W. Foltin
Marian W. Fischman
SELECTIVE GUIDE TO CURRENT REFERENCE SOURCES ON TOPICS DISCUSSED IN THIS ISSUE	107	(12)
Lynn Kasner Morgan
Index	119