Neurobiology of Mental Illness

by Charney, Dennis S.; Nestler, Eric J.; Bunney, Benjamin S.

• ISBN13: 9780195147803
• ISBN10: 0195147804
• Format: Paperback
• Copyright: 2001-04-12
• Publisher: Oxford University Press

Summary

Advances in molecular and cellular biology and in the basic neurosciences are now bringing the revolution in molecular medicine to the field of psychiatry. This is the first comprehensive text to chart that progress. In 70 concise chapters it describes the current state of knowledge aboutthe neurobiological mechanisms underlying psychiatric disorders and shows how this information has the potential to dramatically improve treatment and ultimately lead to prevention. The text has been written by world-renowned experts in basic neuroscience and the pathophysiology and treatment ofpsychiatric disorders. It begins with a concise overview of the basic neurosciences followed by an evaluation of the tools that are available for the study of mental disorders in humans. The core of the book is a series of consistenetly organized sections on affective disorders, anxiety disorders,psychotic disorders, substance abuse disorders, psychiatric disorders in children, and miscellaneous diagnostic entities. Chatpers are written in a clear style that is easily accessible to practicing psychiatrists, and yet they are detailed enough to interest researchers and academics. The book iswell-illustrated and contains selected references that willprove valuable to readers. Both as a textbook and a reference work, Neurobiology of Mental Illness represents a unique and valuable resource for students of medicine, neuroscience and psychology; psychiatric residents and other trainees inthe mental health professions; practicing psychiatrists and psychologists; and other healthcare professionals.

Author Biography

Dennis S. Charney, M.D., is Professor of Psychiatry and Director of the Yale-NIMH Mental Health Research Center; Eric J. Nestler, M.D., Ph.D., is Elizabeth Mears and House Jameson Professor of Psychiatry and Neurobiology; Benjamin S. Bunney, M.D., is Charles B.G. Murphy Professor and Chair, Department of Psychiatry, and Professor of Pharmacology and of Neurobiology; all at the Yale University School of Medicine, New Haven, CT, USA

Table of Contents

Part 1: Basic neurobiology1. Overview of Brain Development2. Neurochemical Systems in the Central Nervous System3. Electrophysiology of Neural Systems4. Principles of Signal Transduction5. Mechanisms of Neural Plasticity6. Principles of Molecular NeurobiologyPart 2: Methods of Clinical Neurobiological Research7. Special Challenges in the Investigation of the Neurobiology of Mental Illness8. Contributions of Epidemiology to the Neurobiology of Mental Illness9. Clinical Molecular Genetics10. Clinical Electrophysiology11. Clinical Neurochemistry12. Clinical Neuroendocrinology13. Clinical Neuroimmunology14. Neuroimaging MethodologiesPart 3: Psychoses15. Diagnostic Classification of the Psychoses: Historical Context andImplications for Neurobiology16. Molecular Genetics of Schizophrenia17. Pharmacologic Models of Psychoses18. Neurodevelopmental Hypothesis of Schizophrenia19. The Neurochemistry of Schizophrenia20. Neuroimaging Studies of Schizophrenia21. Psychophysiological and Information Processing Approaches to Schizophrenia22. Principles of the Pharmacotherapy of SchizophreniaPart 4: Mood Disorders23. Diagnostic Classification of Mood Disorders: Historical Context andImplications for Neurobiology24. Molecular Genetics of Mood Disorders25. Animal Models of Mood Disorders26. The Neurochemistry of Mood Disorders: Preclinical Studies27. The Neurochemsitry of Mood Disorders: Clinical Studies28. Neurobiological Models of Recurrence in Mood Disroders29. Abnormalities of Brain Structure and Function in Mood Disorders30. Neuroimaging Studies of Mood Disorders31. Principls of the Pharmacotherapy of DepressionPart 5: Anxiety Disorders32. Diagnostic Classification of Anxiety Disorders: Historical Context andImplications for Neurobiology33. Molecular Genetics of Anxiety Disorders34. Functional Neuroanatomy of Anxiety and Fear: A Focus on the Amygdala35. The Effects of Stress on Structural and Functional Plasticity in theHippocampus36. The Neurobiology of Anxiety Disorders37. The Neurobiology and Treatment of Obsessive Compulsive Disorder38. Neuroimaging Studies of Obsessive Compulsive Disorder39. Principles of the Pharmacotherapy of the Anxiety DisordersPart 6: Substance Abues Disorders40. Animal Models of Addiction41. Cellular and Molecular Mechanisms of Addiction42. Molecular Genetics of Addiction43. Effects of Alcohol and Cocaine on Brain Development44. Neuroimaging Studies of Substance Abuse Disorders45. Principles of the Pharmacotherpay of Substance Abuse DisordersPart 7: Dementia46. Diagnostic Classifications: Relationship to the Neurobiology of Dementia47. The Molecular Biology of Alzheimer's Disease48. Animal Models of Dementia49. Pharmacological Animal Models of Dementia50. Functional Neuroanatomy of Learning and Memory51. Neurochemical Systems Involved in Learning and Memory52. The Neurochemistry of Dementia53. Neuropathological and Neuroimaging Studies of the Hippocampus in NormalAging and in Alzheimer's Disease54. Abnormalities in Brain Structure of Postmortem Analysis of Dementias55. Neuroimaging Studies of Dementia56. Principles of the Pharmacotherapy of DementiaPart 8: Selected Psychiatric Disorders of Childhood57. Molecular Genetics of Childhood Psychiatric Disorders58. The Neurobiology of Autism and the Pervasive Developmental Disorders59. The Neurobiology of Tourette's Syndrome and Tic Related Disorders inChildren60. The Neurobiology of Attention Deficit Hyperactivity Disorder61. The Neurobiology of Childhood Psychotic Disorders62. The Neurobiology of Child and Adolescent Mood Disorders63. The Neurbiology of Childhood Anxiety DisordersPart 9: Special Topic Areas64. The Neurobiology of Personality and Personality Disorders65. The Neurobiology of Aggression66. The Neurobiology of Human Sexuality67. The Neurobiology of Social Attachment68. The Neurobiology of Eating Disorders69. The Neurobiology of Menstural Cycle Related Mood Disorders70. The Neurobiology of Sleep in Relation to Mental Illness