Neurodevelopment and Schizophrenia

by Edited by Matcheri S. Keshavan , James L. Kennedy , Robin M. Murray

• ISBN13: 9780521126595
• ISBN10: 0521126592
• Edition: 1st
• Format: Paperback
• Copyright: 2010-01-14
• Publisher: Cambridge University Press

Summary

This book was originally published in 1004 and concerns developmental neurobiology. In the decade preceding publication, developmental neurobiology made important strides towards elucidating the pathophysiology of psychiatric disorders. Nowhere has this link between basic science and clinical insights become clearer than in the field of schizophrenia research. Each contributor to this volume provides a fresh overview of the relevant research, including directions for further investigation. The book begins with a section on advances in developmental neurobiology. This is followed by sections on etiological and pathophysiological developments, and models that integrate this knowledge. The final section addresses the clinical insights that emerge from the developmental models. This book will be valuable to researchers in psychiatry and neurobiology, students in psychology, and all mental health practitioners.

Table of Contents

Genes and brain development

Brain development in healthy children and adolescents: magnetic resonance imaging studies

Cognitive development: fMRI studies

Cognitive development in adolescence: cerebral underpinnings, neural trajectories and the impact of aberrations

Brain plasticity and long-term function after early cerebral insult: the example of very preterm birth

Do degenerative changes operate across diagnostic boundaries? The case for glucocorticoids involvement in major psychiatric disorders

Velo-cardio-facial syndrome (deletion 22q11.2): a homogeneous neurodevelopmental model for schizophrenia

Can structural MRI provide an alternative phenotype for genetic studies of schizophrenia?

Nutritional factors and schizophrenia

Schizophrenia, neurodevelopment, and epigenetics

Early environmental risk factors for schizophrenia

Transcriptomes in schizophrenia: assessing altered gene expression with microarrays

Is there a role for social factors in a comprehensive development model for schizophrenia?

How does drug abuse interact with familial and developmental factors in the aetiology of schizophrenia?

Developmental dysregulation of the dopamine system and the pathophysiology of schizophrenia

The development of 'mis-wired' limbic lobe circuitry in schizophrenia and bipolar disorder

Development of thalamocortical circuitry and the pathophysiology of schizophrenia

X chromosome, estrogen, and brain development, implications for schizophrenia

Premorbid structural abnormalities in schizophrenia

Neurodegenerative models of schizophrenia

Does disordered brain development cut across diagnostic boundaries?

Can one identify preschizophrenic children?

High risk studies, brain development and schizophrenia

Developmental models and hypotheses-driven early interventions in schizophrenia

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