This book was originally published in 1004 and concerns developmental neurobiology. In the decade preceding publication, developmental neurobiology made important strides towards elucidating the pathophysiology of psychiatric disorders. Nowhere has this link between basic science and clinical insights become clearer than in the field of schizophrenia research. Each contributor to this volume provides a fresh overview of the relevant research, including directions for further investigation. The book begins with a section on advances in developmental neurobiology. This is followed by sections on etiological and pathophysiological developments, and models that integrate this knowledge. The final section addresses the clinical insights that emerge from the developmental models. This book will be valuable to researchers in psychiatry and neurobiology, students in psychology, and all mental health practitioners.

List of contributors

viii

Foreword

xiii

Preface

xvii

Part I Basic aspects

Genes and brain development

3

(32)

Timothy A. Klempan

Pierandrea Muglia

James L. Kennedy

Brain development in healthy children and adolescents: magnetic resonance imaging studies

35

(10)

Jay N. Giedd

Michael A. Rosenthal

A. Blythe Rose

Jonathan D. Blumenthal

Elizabeth Molloy

Richard R. Dopp

Liv S. Clasen

Daniel J. Fridberg

Nitin Gogtay

Cognitive development: functional magnetic resonance imaging studies

45

(24)

Beatriz Luna

John A. Sweeney

Cognitive development in adolescence: cerebral underpinnings, neural trajectories, and the impact of aberrations

69

(20)

Stephen J. Wood

Cinzia R. De Luca

Vicki Anderson

Christos Pantelis

Brain plasticity and long-term function after early cerebral insult: the example of very preterm birth

89

(22)

Matthew Allin

Chiara Nosarti

Larry Rifkin

Robin M. Murray

Part II Etiological factors

Do degenerative changes operate across diagnostic boundaries? The case for glucocorticoid involvement in major psychiatric disorders

111

(10)

Carmine M. Pariante

David Cotter

Velo-cardio-facial syndrome (deletion 22q11.2): a homogeneous neurodevelopmental model for schizophrenia

121

(17)

Stephan Eliez

Carl Feinstein

Can structural magnetic resonance imaging provide an alternative phenotype for genetic studies of schizophrenia?

138

(18)

Colm McDonald

Robin M. Murray

Nutritional factors and schizophrenia

156

(18)

Sahebarao P. Mahadik

Schizophrenia, neurodevelopment, and epigenetics

174

(17)

Arturas Petronis

Early environmental risk factors for schizophrenia

191

(19)

Mary Cannon

Kimberlie Dean

Peter B. Jones

Transcriptomes in schizophrenia: assessing altered gene expression with microarrays

210

(14)

David A. Lewis

Karoly Mirnics

Pat Levitt

Is there a role for social factors in a comprehensive development model for schizophrenia?

224

(24)

Jane Boydell

Jim van Os

Robin M. Murray

How does drug abuse interact with familial and developmental factors in the etiology of schizophrenia?

248

(25)

Chih-Ken Chen

Robin M. Murray

Part III Pathophysiology

Developmental dysregulation of the dopamine system and the pathophysiology of schizophrenia

273

(22)

Anthony A. Grace

The development of ``mis-wired'' limbic lobe circuitry in schizophrenia and bipolar disorder

295

(15)

Francine M. Benes

Development of thalamocortical circuitry and the pathophysiology of schizophrenia

310

(20)

Darlene S. Melchitzky

David A. Lewis

X chromosome, estrogen, and brain development: implications for schizophrenia

330

(17)

Michael Craig

William Cutter

Ray Norbury

Declan Murphy

Premorbid structural abnormalities in schizophrenia

347

(26)

Stephen M. Lawrie

Neurodegenerative models of schizophrenia

373

(17)

L. Fredrik Jarskog

John H. Gilmore

Jeffrey A. Lieberman

Does disordered brain development occur across diagnostic boundaries?

390

(25)

Christian W. Kreipke

David R. Rosenberg

Matcheri S. Keshavan

Part IV Clinical implications

Can one identify preschizophrenia children?

415

(17)

Eugenia Kravariti

Paola Dazzan

Paul Fearon

Robin M. Murray

High-risk studies, brain development, and schizophrenia

432

(23)

Matcheri S. Keshavan

Developmental models and hypothesis-driven early interventions in schizophrenia

455

(18)

Matcheri S. Keshavan

Barbara A. Cornblatt

Index

473

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