A panel of leading experts integrate the latest findings from basic and clinical science to create a comprehensive treatment of the processes by which the brain acts as an endocrine organ, not only to control hormonal functions, but also to maintain homeostasis and regulate behavior. The authors-recognized both as leaders in their fields and as skilled teachers-provide systematic coverage of the analytical, anatomical, functional, clinical, and pathological aspects of neuroendocrinology. Topics range from the interactions between the nervous and endocrine systems to the regulation of reproduction, development, metabolism, fluid balance, and biological rhythms. Neuroendocrinology in Physiology and Medicine offers an unprecedented marriage of clinical and basic knowledge that has been missing from classical neuroscience, endocrinology, and physiology texts. It will teach today's medical students and serve researchers as a valuable reference to this rapidly growing field.

Preface

v

Contributors

xi

Part I. The Interactions Between the Nervous and Endocrine Systems

The Hypothalamus as an Endocrine Organ: The Science of Neuroendocrinology

3

(20)

Bela Halasz

Micro- and Macroscopic Structure, Innervation, and Vasculature of the Hypothalamus

23

(18)

Miklos Palkovits

Hypothalamic Hormones

41

(18)

Akira Arimura

Neurotransmitters as Regulators of Hypothalamic Function

59

(16)

Paul V. Malven

The Hypothalamus as a Major Integrative Center

75

(20)

Jon E. Levine

Endocrine Targets in the Brain

95

(12)

Lothar Jennes

M. Chris Langub

Part II. Neuroendocrine Regulation of Reproduction, Parturition, Lactation, Growth, Development, Metabolism, and Fluid Balance

Neuroendocrine Regulation of Pituitary Function: General Principles

107

(28)

George Fink

Neuroendocrine Regulation of Reproductive Cyclicity

135

(12)

Neena B. Schwartz

Neuroendocrine Regulation of Pregnancy and Parturition

147

(16)

John R. G. Challis

Neuroendocrine Regulation of Lactation and Milk Ejection

163

(18)

H. Allen Tucker

Neuroendocrine Regulation of Growth Hormone Secretion

181

(16)

William B. Wehrenberg

Andrea Giustina

Neuroendocrine Regulation of Puberty

197

(28)

Sergio R. Ojeda

Marie Bilger

Neuroendocrine Regulation of Thyroid Function

225

(16)

William J. DeVito

Neuroendocrine Regulation of Water Balance: The Kidney

241

(20)

Leonard Share

Edward G. Schneider

Part III. Neuroendocrine Correlates of Stress, Behavior, and Biological Processes

Regulation of the Stress Response by Corticotropin-Releasing Factor Receptors

261

(26)

Richard L. Hauger

Frank M. Dautzenberg

Neuroendocrine Regulation of Sexual Behavior

287

(14)

Donald W. Pfaff

Nandini Vasudevan

Barbara Attardi

Neuroendocrine Regulation of Maternal Behavior

301

(16)

Robert S. Bridges

Elizabeth M. Byrnes

Neuroendocrine Regulation of Fluid Intake and Homeostasis

317

(18)

Joseph G. Verbalis

Edward M. Stricker

Control of Food Intake

335

(18)

Peter J. Havel

Philip J. Larsen

Judy L. Cameron

Neuroendocrine Regulation of Learning and Memory

353

(18)

Tj. B. van Wimersma Greidanus

G. Croiset

David de Wied

Neuroendocrine Correlates of Aging

371

(20)

Phyllis M. Wise

Part IV. Neuroendocrine Regulation of Biological Rhythms

Chronobiology

391

(14)

Gene D. Block

Marie Kerbeshian

Erik D. Herzog

Influence of Light and the Pineal Gland on Biological Rhythms

405

(16)

Henryk F. Urbanski

Neuroendocrine Regulation of Biological Rhythms

421

(14)

Nancy L. Wayne

The Neuroendocrine Control of Circadian Rhythms

435

(18)

Benoit Malpaux

The Neuroendocrine Control of Ultradian Rhythms

453

(22)

Johannes D. Veldhuis

Part V. Neuroendocrine Pathology and Disease

Diagnosis and Treatment of Hypothalamic Disease

475

(24)

Marcello D. Bronstein

Malebranche B. C. Cunha Neto

Nina Rosa de C. Musolino

Hypothalamic Involvement in Disorders of Pituitary Hormone Secretion

499

(10)

Ilan Shimon

Shlomo Melmed

Part VI. Emerging Areas of Neuroendocrinology

Neuroendocrine Immunology

509

(18)

Charles V. Clevenger

Loretta M. Flanagan-Cato

Electrophysiology of Hypothalamic Neurons

527

(14)

F. Edward Dudek

Bret N. Smith

Kelly J. Suter

Jean-Pierre Wuarin

Anatomical Markers of Activity in Hypothalamic Systems

541

(12)

Gloria E. Hoffman

Anne Z. Murphy

Index

553

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