Neuroimmunology of the Skin

by Granstein, Richard D.; Luger, Thomas A.

• ISBN13: 9783540359869
• ISBN10: 3540359869
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-11-01
• Publisher: Springer Verlag

Summary

Much anecdotal information has suggested an influence of psychology and the nervous system on immunity within the skin and the expression of inflammatory skin disorders. Recent years have seen an explosion of knowledge providing a scientific basis for important regulatory interactions between the nervous system, the endocrine system and the immune system within the skin. The results of recent investigations have important implications, not only for an understanding of cutaneous immunity, but also for the development of novel treatments for diseases involving abnormal inflammation or immune reactivity within the skin. This book provides a comprehensive and interdisciplinary review of the molecular biology, cell biology, biochemistry and clinical aspects of nervous system-immune system interactions within the skin. It includes contributions from leading world experts in these areas. The contents are relevant to both investigators and clinicians interested in the skin, its functions and its disorders. Book jacket.

Table of Contents

Basic Neuroimmunology of the Skin
Neuroanatomy of the Skin	p. 3
Neuroreceptors and Mediators	p. 13
Autonomic Effects on the Skin	p. 23
Immune Circuits of the Skin	p. 33
Modulation of Immune Cells by Products of Nerves	p. 45
Regulation of Immune Cells by POMC Peptides	p. 55
Regulation of Cutaneous Immunity by Catecholamines	p. 65
The Role of Neuropeptide Endopeptidases in Cutaneous Immunity	p. 75
Neuroinflammation and Toll-Like Receptors in the Skin	p. 89
Stress and Cutaneous Immunity
Neuroendocrine Regulation of Skin Immune Response	p. 105
Effects of Psychological Stress on Skin Immune Function: Implications for Immunoprotection Versus Immunopathology	p. 113
Photoneuroimmunology: Modulation of the Neuroimmune System by UV Radiation	p. 125
Neurobiology of Skin Appendages
Neurobiology of Hair	p. 139
Neurobiology of Sebaceous Glands	p. 159
Neurobiology of Skin Appendages: Eccrine, Apocrine, and Apoeccrine Sweat Glands	p. 167
The Nervous System and the Pathophysiology of Skin Disorders
Neurophysiology of Itch	p. 179
Neuroimmunologic Cascades in the Pathogenesis of Psoriasis and Psoriatic Arthritis	p. 187
Neuroimmunology of Atopic Dermatitis	p. 197
Stress and Urticaria	p. 209
Acne Vulgaris and Rosacea	p. 219
Wound Healing and Stress	p. 233
Index	p. 249
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