Neurological Disorders and Pregnancy

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2010-12-01
  • Publisher: Elsevier Science Ltd

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Timely diagnosis and management of neurological diseases during pregnancy poses major therapeutic challenges to neurologists and other non-neurologists health care providers. Pregnancy is a unique period in life which is associated with significant hormonal and other physiologic changes in female patients which may trigger or alter the course of neurological and psychiatric disorders. In addition, many diagnostic procedures which can be performed in non-pregnant women are prohibited during pregnancy for safety reasons. Therapeutic decisions and management of a pregnant patient with neurological disorders heavily depends on the issue of the reasonable balance between the risks of no-treatment versus active treatment for the mother and her fetus.This book provides a review of the latest findings in this field providing both the neurologist and non-neurologist with the information they need in order to determine the best treatment. Neurological disorders covered include multiple sclerosis, stroke and epilepsy. Discusses how neurological disorders should be managed in a pregnant patient Includes contributions from leading authorities

Table of Contents

Prefacep. ix
Contributorsp. xi
Pregnancy and Multiple Sclerosisp. 1
Introductionp. 1
How Pregnancy Affects the Disease Activityp. 2
Pregnancy Outcome Among MS Mothersp. 3
Treatment of MS Mothers During Pregnancy and Lactationp. 4
Immunologic Basis of Pregnancy-Induced Disease Remissionp. 6
Conclusionp. 8
Headache in Pregnancyp. 13
Introductionp. 13
Epidemiology of Headache in Pregnancyp. 13
Pathophysiology of Primary Headache During Pregnancyp. 18
Management of Primary Headache in Pregnancyp. 22
Pharmacologic Treatmentsp. 25
Secondary Headaches and Their Managementp. 32
Conclusionp. 44
Myasthenia Gravis and Pregnancyp. 55
Introductionp. 55
Clinical Featuresp. 55
Diagnosisp. 56
General Aspects of Preconception Carep. 57
Effect of Preganancy on MGp. 57
Effect of MG in Pregnancyp. 58
Treatmentp. 60
Labor and Deliveryp. 63
Effects on the Fetus and Neonatep. 65
Postpartum Angiopathy and Related Disordersp. 69
Background and Contextp. 69
Postpartum Angiopathyp. 69
Neurology of Pre-eclampsia and Eclampsiap. 79
Pathophysiologyp. 79
Neurologic Manifestations of Pre-eclampsia/Eclampsiap. 80
Cerebrovascular Diseasep. 82
Epilepsyp. 85
Neurobehavioral Aspects of Pre-eclampsia/Eclampsiap. 87
Epilepsy and Pregnancyp. 91
Introductionp. 91
Historyp. 92
Fertility and Epilepsyp. 94
Contraception and Epilepsyp. 96
The Effect of Pregnancy on Epilepsyp. 97
The Effects of Epilepsy on Pregnancyp. 100
Eclampsiap. 101
Effects of Maternal Seizures on the Developing Fetusp. 107
Effects of Epilepsy Treatment on the Developing Fetusp. 108
Evaluation of a First Seizure in a Pregnant Patientp. 110
Summaryp. 114
Movement Disorders and Pregnancyp. 123
Introductionp. 123
Parkinson's Diseasep. 123
Chorea Gravidarump. 125
Huntington's Diseasep. 126
Dystoniap. 126
Essential Tremorp. 127
Wilson's Diseasep. 128
Restless Legs Syndromep. 129
Tourette's Syndromep. 129
Conclusionsp. 130
Psychiatric Disorders and Pregnancyp. 135
Introductionp. 135
Schizophrenia and Pregnancyp. 135
Course of Schizophrenia During Pregnancy and Postpartump. 137
Antipsychotic Medications and Pregnancyp. 138
BPD and Pregnancyp. 143
Postpartum Depressionp. 145
Anxiety Disorders and Pregnancyp. 147
Eating Disorders and Pregnancyp. 151
Conclusionp. 152
Neuromuscular Diseases in Pregnancyp. 159
Pathophysiologyp. 159
Neuromuscular Diseases that Result from Pregnancy, Labor, and the Postpartum Periodp. 161
Muscle Crampsp. 166
Pregnancy and Underlying Neuromuscular Diseasep. 166
Inflammatory Neuropathiesp. 167
Hereditary Neuropathiesp. 169
Autoimmune Inflammatory Myopathiesp. 170
Hereditary Myopathiesp. 171
Motor Neuron Diseasesp. 175
Sleep Disorders and Pregnancyp. 185
Regular Sleep Duration and Pattern in Pregnancyp. 185
Sleep Deprivation in Pregnancyp. 186
Sleep-Disordered Breathing in Pregnancyp. 188
Other Sleep Disorders in Pregnancyp. 197
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