Neuronal and Cognitive Effects of Oestrogens

by Chadwick, Derek J.; Goode, Jamie A.

• ISBN13: 9780471492030
• ISBN10: 0471492035
• Edition: 1st
• Format: Hardcover
• Copyright: 2000-08-22
• Publisher: WILEY

Summary

Although normally thought of as a sex hormone, recent research has highlighted the numerous and significant effects that oestrogen has on the CNS, extending far beyond its important reproductive role. It has been shown that oestrogen acts as a neural growth factor with important influences on the survival, plasticity, regeneration and ageing of the mammalian brain. This exciting book brings together leading clinicians and researchers to discuss oestrogen's basic mechanisms of action, the extrahypothalmic brain regions it affects, and its influence on cognitive functions in animals and humans. Finally, recent research on the role of oestrogens in ageing and dementia, including the significance of oestrogen action in Alzheimer's disease, is discussed. The 15 papers contained in this book, together with the extensive discussion sessions that follow them, reveal much new and exciting work in this area, and identify promising new research directions.

Author Biography

Derek J. Chadwick and Jamie A. Goode are editors for Neuronal and Cognitive Effects of Oestrogens and other scientific titles.

Table of Contents

Editors
Derek J. Chadwick
Jamie A. Goode
This symposium is based on a proposal made
Bruce McEwen
Chairman's introduction	1	(6)
Bruce McEwen
Mechanism of oestrogen signalling with particular reference to the role of ERβ in the central nervous system	7	(13)
Eckardt Treuter
Margaret Warner
Jan-Ake Gustafsson
Discussion	15	(5)
Oestrogen receptor function at classical and alternative response elements	20	(13)
Peter J. Kushner
David Agard
Wei-Jun Feng
Gabriela Lopez
Andrew Schiau
Rosalie Uht
Paul Webb
Geoffrey Greene
Discussion	27	(6)
General discussion I	33	(119)
Nuclear receptor versus plasma membrane oestrogen receptor	41	(15)
Ellis R. Levin
Discussion	50	(6)
Novel sites and mechanisms of oestrogen action in the brain	56	(18)
C. Dominique Toran-Allerand
Discussion	69	(5)
Oestrogen modulation of noradrenaline neurotransmission	74	(20)
Allan E. Herbison
Sharon X. Simonian
Niren R. Thanky
R. John Bicknell
Discussion	85	(9)
Oestrogen and the cholinergic hypothesis: implications for oestrogen replacement therapy in postmenopausal women	94	(18)
Robert B. Gibbs
Discussion	107	(5)
Ovarian steroid action in the serotonin neural system of macaques	112	(22)
Cynthia L. Bethea
Chrisana Gundlah
Stephanie J. Mirkes
Discussion	130	(4)
Oestrogen effects on dopaminergic function in striatum	134	(18)
Jill B. Becker
Discussion	145	(7)
General discussion II	152	(122)
Oestrogen effects in olivo-cerebellar and hippocampal circuits	155	(18)
Sheryl S. Smith
Fu-Chun Hsu
Xinshe Li
Cheryl A. Frye
Donald S. Faber
Ronald S. Markowitz
Discussion	168	(5)
Effects of oestradiol on hippocampal circuitry	173	(15)
Catherine S. Woolley
Discussion	181	(7)
Oestrogen and cognitive function throughout the female lifespan	188	(14)
Barbara B. Sherwin
Discussion	196	(6)
Neuroprotective effects of phenolic A ring oestrogens	202	(19)
Pattie S. Green
Shao-Hua Yang
James W. Simplins
Discussion	213	(8)
The female sex hormone oestrogen as neuroprotectant: activities at various levels	221	(18)
Christian Behl
Bernd Moosmann
Dieter Manthey
Stefanie Heck
Discussion	234	(5)
Neurohormonal signalling pathways and the regulation of Alzheimer β-amyloid metabolism	239	(15)
Sam Gandy
Suzana Petanceska
Discussion	251	(3)
Oestrogens and dementia	254	(20)
Victor W. Henderson
Discussion	265	(9)
Index of contributors	274	(2)
Subject index	276