Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy

by Van Leeuwen; Salehi; Giger; Holtmaat; Verhaagen

• ISBN13: 9780444828170
• ISBN10: 0444828176
• Edition: 1st
• Format: Hardcover
• Copyright: 1998-11-09
• Publisher: Elsevier Science

Summary

This book is the result of the 20th International Summer School in Brain Research, organized in August 1997 in Amsterdam, by the Netherlands Institute for Brain Research at the Royal Netherlands Academy of Sciences. It is the first book that provides a complete overview of the field of neurodegeneration and regeneration including spinal cord injury, neurodegenerative diseases and therapy. Divided into five sections, the first two sections give an overview of fundamental research on nerve cell death, neuronal survival, neurite outgrowth and guidance. Extensive attention is given to the role of neurotrophins, their receptor tyrosine kinases and cell-adhesion molecules in development and regeneration of the nervous system. The third section of the book is devoted to research involving human neurodegenerative diseases and emerging treatment strategies. Section four focusses on recent advances in the understanding of pathophysiological mechanisms underlying neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases along with prion diseases. Novel insights into the neuropathological hallmarks of these diseases, as well as into transgenic animal models, the involvement of environmental factors, and genomic and mRNA changes that can cause neurodegeneration. The final section of this volume reveals recent developments in the use of cell and gene therapy to treat neurodegenerative disease and lesion-related deficits. Implantation of genetically modified cells, direct gene transfer with viral vectors and the first clinical trials with encapsulated genetically modified cells in patients suffering from amyotrophic lateral scelerosis are examples of new therapeutic strategies treating neurodegenerative diseases.The book is of particular interest to departments of neuroscience, neurological clinics and departments, the pharmalogical industry and medical libraries.

Table of Contents

List of contributors	v
Preface	xi
Acknowledgements	xiii
Mechanisms of nerve cell death and nerve cell survival
Neuronal cell death: an updated view	3	(6)
L.L. Rubin
Corticosteroid hormones and neuronal vulnerability: towards indentification of candidate vulnerability genes	9	(14)
E. Vreugdenhil
E.R. de Kloet
Ubiquitin and its role in neurodegeneration	23	(12)
J. Arnold
S. Dawson
J. Fergusson
J. Lowe
M. Landon
R.J. Mayer
Studying signal transduction in neuronal cells: the Trk/NGF system	35	(12)
D.R. Kaplan
Developmental changes in the neurotrophic factor survival requirements of peripheral nervous system neurons	47	(10)
A.M. Davies
Regulation of brain-derived neurotrophic factor mRNA levels in hippocampus by neuronal activity	57	(8)
E. Castren
B. Berninger
A. Leingartner
D. Lindholm
Instructive roles of neurotrophins in synaptic plasticity	65	(6)
D.C. Lo
Neurotrophin receptors in Alzheimer's disease	71	(22)
A. Salehi
J. Verhaagen
D.F. Swaab
Biological factors that determine neuronal differentiation, axonal growth, guidance and target recognition
Discrete clusters of axonin-I and NgCAM at neuronal contact sites: facts and speculations on the regulation of axonal fasciculation	93	(12)
P. Sonderegger
S. Kunz
C. Rader
A. Buchstaller
P. Berger
L. Vogt
S.V. Kozlov
U. Ziegler
B. Kunz D. Fitzli
E.T. Stoeckli
Molecular mechanisms of commissural axon pathfinding	105	(10)
E.T. Stoeckli
Semaphorin-mediated neuronal growth cone guidance	115	(18)
A.L. Kolodkin
Semaphorin III: role in neuronal development and structural plasticity	133	(18)
R.J. Giger
R.J. Pasterkamp
A.J.G.D. Holtmaat
J. Verhaagen
Role for semaphorin III and its receptor neuropilin-I in neuronal regeneration and scar formation?	151	(20)
R.J. Pasterkamp
F. De Winter
R.J. Giger
J. Verhaagen
EPH receptors and ligands in axon pathway choice, target recognition, and synaptogenesis	171	(8)
G. Lemke
The role of glial cells in neurodegeneration and regeneration
Boundary molecules during brain development, injury, and persistent neurogenesis -- in vivo and in vitro studies	179	(18)
D.A. Steindler
V.G. Kukekov
L. Brannon Thomas
H. Fillmore
O. Suslov
B. Scheffler
T.F. O'Brien
M. Kusakabe
E.D. Laywell
Cellular activation in neuroregeneration	197	(14)
F.-W. Schwaiger
G. Hager
G. Raivich
G.W. Kreutzberg
Cellular and molecular correlates of the regeneration of adult mammalian CNS axons into peripheral nerve grafts	211	(22)
P.N.
G. Campbell
Y. Zhang
A.R. Lieberman
Oligodendrocyte regeneration in the adult rodent CNS and the failure of this process in multiple sclerosis	233	(16)
G. Wolswijk
Genetic basis of peripheral neuropathies	249	(18)
L.J. Valentijn
F. Baas
Critical events in neurodegenerative diseases, prion diseases and multiple sclerosis
Neuropathological hallmarks of Alzheimer's and Parkinson's diseases	267	(20)
H. Braak
R.A.I. de Vos
E.N.H. Jansen
H. Bratzke
E. Braak
Neurofibrillary pathology of Alzheimer's disease and other tauopathies	287	(20)
M. Goedert
A new approach to the genetic analysis of nervous system diseases: retrospective genotyping of archival brains	307	(8)
S. Kosel. E.M. Grasbon-Frodl
M.B. Graebe
Alzheimer's disease: identification of genes and genetic risk factors	315	(12)
C. Van Broeckhoeven
Neurodegenerative Alzheimer-like pathology in PDAPP 717V--- F transgenic mice	327	(8)
K.S. Chen
E. Masliah
H. Grajeda
T. Guido
J. Huang
K. Khan
R. Motter
F. Soriano
D. Games
Strain dependent and invariant features of transgenic mice expressing Alzheimer amyloid precursor proteins	335	(8)
K. Hsiao
Reduced neuronal activity and reactivation in Alzheimer's disease	343	(36)
D.F. Swaab
P.J. Lucassen
A. Salehi
E.J.A. Scherder
E.J.W. van Someren
R.W.H. Verwer
Dinucleotide deletions in neuronal transcripts: a novel type of mutation in non-familial Alzheimer's disease and Down syndrome patients	379	(18)
E.M. Hol
A. Neubauer
D.P.V. de Kleijn
J.A. Sluijs
R.D.J. Ramdjielal
M.A.F. Sonnemans
F.W. van Leeuwen
Pathogenesis of neurodegenerative disease associated with expanded glutamine repeats: new answers, new questions	397	(24)
C.A. Ross
R.L. Margolis
M.W. Becher
J.D. Wood
S. Engelender
J.K. Cooper
A.H. Sharp
Molecular studies of prion diseases	421	(14)
J. Safar
S.B. Prusiner
The small heat shock protein αB-crystallin as kem autoantigen in multiple sclerosis	435	(20)
J.M. Van Noort
A.C. van Sechel
M.J.B. van Stipdonk
J.J. Bajramovic
Strategies to promote regeneration of injured neurons: direct intervention and neural replacement
Spinal cord injury: bridging the lesion and the role of neurotrophic factors in repair	455	(18)
D.A. Houweling
P.R. Bar
W.H. Gispen
E.A.J. Joosten
Neurotrophin gene therapy in CNS models of trauma and degeneration	473	(12)
A. Blesch
R.J. Grill
M.H. Tuszynski
Gene therapy for inherited neurological disorders: towards therapeutic intervention in the Lesch--Nyhan syndrome	485	(18)
P.R. Lowenstein
T.D. Southgate
J.R. Smith-Arica
J. Smith
M.G. Castro
Towards gene therapy of neurodegenerative disease	503	(8)
H.J. Federoff
M. Atkinson
Prospectives for cell and gene therapy in Huntington's disease	511	(14)
A.-C. Bachoud-Levi
P. Hantraye
M. Peschanski
Index	525