Neuroprotective Agents Seventh International Conference, Volume 1053

by Slikker, William; Andrews, Russell J.; Trembly, Bruce

• ISBN13: 9781573315791
• ISBN10: 1573315796
• Edition: 1st
• Format: Paperback
• Copyright: 2005-09-23
• Publisher: Wiley-Blackwell

Summary

As life expectancy has increased, so has the incidence of neurodegenerative diseases, particularly those associated with aging. Contributing to increased life expectancy is increased survival following brain injury, stroke, and procedures such as heart surgery, but these events can impair neurological function.The wide range of contributions to this volume, from a detailed paper on the use of gene therapy in combination with hypothermia for the treatment of cerebral ischemia to a comprehensive poster describing the role of anesthetic agents in neurotoxicity during development and senescence, illustrate the scientific scope presented.Contributions from clinical and basic science researchers from many disciplines address various approaches to providing neuroprotection. The clinical focus is on the complexity of neuroprotection, the need for understanding the time-course effects of hypoxia/ischemia, and the need for combinational and time-course applications of multiple therapies. New technologies are introduced for describing both the insult and the treatment necessary for neuroprotection, including gene expression assays (genomics) and gene therapy.Several chapters are devoted to the examination of the predictive value of models for outcome measures in clinical ischemic stroke neuroprotective trials. The need to move from in vitro models to more predictive in vivo approaches with the use of pharmacokinetics is addressed. Other chapters emphasize the role of endogenous agents such as nitric oxide, melatonin, L-carnitine, and estrogens in acute and chronic neural injury and therapy.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Author Biography

William Slikker Jr is the editor of Neuroprotective Agents: Seventh International Conference, Volume 1053, published by Wiley. Russell J. Andrews is the editor of Neuroprotective Agents: Seventh International Conference, Volume 1053, published by Wiley.

Table of Contents

Preface	xi
William Slikker Jr.
Russell J. Andrews
Bruce Trembly
Session I. The Human Experience of Neuroprotection
Neuroprotection Trek---The Next Generation: The Measurement Is the Message.	1	(11)
Russell J. Andrews
Protective Effect of Neuromonitoring during Cardiac Surgery.	12	(8)
Harvey L. Edmonds, Jr.
Neuropsychiatric Alterations in MDMA Users: Preliminary Findings.	20	(8)
Ronald I. Herning
Warren Better
Kimberly Tate
Jean L. Cadet
Intraoperative Monitoring during Aneurysm Surgery as a Neuroprotective Activity with Reference to Evoked Potential and Microvascular Doppler Techniques.	28	(2)
Karl E. Sanzenbacher
Panel of Biomarkers Predicts Stroke.	30	(1)
D. T. Laskowitz
R. Blessing
J. Floyd
W. D. White
J. R. Lynch
Evaluating Neuroprotective Agents in Coronary Artery Bypass Surgery.	31	(8)
Stanton Newman
Questions and Answers: Session I	32	(7)
Session II. Mechanisms of Neuroprotection (1)
Delineating and Understanding Cerebellar Neuroprotective Pathways: Potential Implication for Protecting the Cortex.	39	(9)
Xuan Wu
Xueying Jiang
Ann M. Marini
Robert H. Lipsky
A Role for Calpain in Optic Neuritis.	48	(7)
M. Kelly Guyton
Eric A. Sribnick
Swapan K. Ray
Naren L. Banik
Activation of Neuroprotective Pathways by Metabotroic Group I Glutamate Receptors: A Potential Target for Drug Discovery?	55	(19)
Andrius Baskys
Liwei Fang
Ildar Bayazitov
Antiapoptotic and Anti-inflammatory Mechanisms of Heat-Shock Protein Protection.	74	(10)
Midori A. Yenari
Jialing Liu
Zhen Zheng
Zinaida S. Vexler
Jong Eun Lee
Rona G. Giffard
Neuroprotection by NGF in the PC12 In Vitro OGD Model: Involvement of Mitogen-Activated Protein Kinases and Gene Expression	84	(13)
Rinat Tabakman
Hao Jiang
Iris Shahar
Hadar Arien-Zakay
Robert A. Levine
Philip Lazarovici
Role of Peroxynitrite in Methamphetamine-Induced Dopaminergic Neurodegeneration and Neuroprotection by Antioxidants and Selective NOS Inhibitors	97	(10)
Syed F. Ali
Syed Z. Imam
Yossef Itzhak
Questions and Answers: Session II	99	(8)
Session III. Neuroprotection in Inflammation-Related Neurodegenerative Diseases
Microglial NADPH Oxidase Mediates Leucine Enkephalin Dopaminergic Neuroprotection	107	(14)
Liya Qin
Yuxin Liu
Xun Qian
Jau-Shyong Hong
Michelle L. Block
Effect of Neuroprotective Drugs on Gene Expression in G93A/SODI Mice.	121	(16)
Sheila Ignacio
Dan H. Moore
Andrew P. Smith
Nancy M. Lee
Brain Response to Injury and Neurodegeneration: Endogenous Neuroprotective Signaling.	137	(11)
Nicolas G. Bazan
Victor L. Marcheselli
Kasie Cole-Edwards
Early Effects of Modulating Nuclear Factor-κB Activation on Traumatic Spinal Cord Injury in Rats.	148	(3)
Octavio Jimenez-Garza
Javier Camacho
Antonio Ibarra
Angelina Martinez
Gabriel Guizar-Sahagun
Role of Inflammation in the Pathogenesis of Parkinson's Disease: Models, Mechanisms, and Therapeutic Interventions.	151	(2)
Jau-Shyong Hong
Session IV. Role of Carnitines and Other Agents in Neuroprotection
Mechanisms of Ischemic Neuroprotection by Acetyl-L-carnitine.	153	(9)
Santina A. Zanelli
Nina J. Solenski
Robert E. Rosenthal
Gary Fiskum
Identification of Rat Hippocampal mRNAs Altered by the Mitochondrial Toxicant 3-NPA.	162	(12)
Beata D. Przybyla-Zawislak
Brett T. Thorn
Syed F. Ali
Richard A. Dennis
Antonino Amato
Ashraf Virmani
Zbigniew K. Binienda
Carnitine and Neuroprotection in the Animal Model of Mitochondrial Dysfunction.	174	(9)
Zbigniew Binienda
Beata Przybyla-Zawislak
Ashraf Virmani
Larry Schmued
Effects of Metabolic Modifiers Such as Carnitines, Coenzyme Q10, and PUFAs against Different Forms of Neurotoxic Insults: Metabolic Inhibitors, MPTP, and Methamphetamine.	183	(12)
Ashraf Virmani
Franco Gaetani
Zbigniew Binienda
Questions and Answers: Session IV	192	(3)
Session V. Neuroprotective Approaches and Models
The Antiapoptotic Actions of Mood Stabilizers: Molecular Mechanisms and Therapeutic Potentials.	195	(10)
De-Maw Chuang
Circulatory Arrest as a Model for Studies of Global Ischemic Injury and Neuroprotection.	205	(15)
Lars Wiklund
Hari Shanker Sharma
Samar Basu
Possible Neuroprotective Mechanism of Human Neuroglobin.	220	(11)
Keisuke Wakasugi
Chihiro Kitatsuji
Isao Morishima
The Impact of Aging, Dietary Restriction, and Glucocorticoids on ApoE Gene Expression in Rat Brain.	231	(6)
S. Ruzdijic
M. Perovic
A. Mladenovic
D. Milanovic
L. Rakic
S. Petanceska
S. Kanazir
Questions and Answers: Session V	233	(4)
Session VI. Neuroprotective Agents and Mechanisms
Saposin C: Neuronal Effect and CNS Delivery by Liposomes.	237	(10)
Zhengtag Chu
Ying Sun
Chia Yi Kuan
Gregory A. Grabowski
Xiaoyang Qi
Brain-Derived Neurotrophic Factor Is Neuroprotective against Human Immunodeficiency Virus-I Envelope Proteins	247	(11)
Alessia Bachis
Italo Mocchetti
Nicotinamide Modulates Energy Utilization and Improves Functional Recovery from Ischemia in the In Vitro Rabbit Retina.	258	(11)
Diamond Tam
Majestic Tam
Kenneth I. Maynard
Mechanisms of Disease: Motoneuron Disease Aggravated by Transgenic Expression of a Functionally Modified AMPA Receptor Subunit.	269	(20)
Rohini Kuner
Anthony J. Groom
Gerald
Muller
Hans-Christian Kornau
Vanya Stefovska
Iris Bresink
Bettina Hartmann
Karsten Tschauner
Stefan Waibel
Albert C. Ludolph
Chrysanthy Ikonomidou
Peter H. Seeburg
Lechoslaw Turski
Questions and Answers: Session VI	287	(2)
Session VII. The NMDA Receptor as a Target for Neurotoxicity and Neuroprotection
Potentially Neuroprotective and Therapeutic Properties of Nitrous Oxide and Xenon.	289	(12)
Jacques H. Abraini
Helene N. David
Marc Lemaire
Chronic Exposure to Nitrous Oxide Increases [3H]MK801 Binding in the Cerebral Cortex, but Not in the Hippocampus of Adult Mice.	301	(8)
Natascha Sommer
Carmelo Romano
Vesna Jevtovic-Todorovic
Systems Biology/Systems Toxicology: Application to Developmental Neurotoxicology/Neuroprotection.	309	(2)
William Slikker Jr.
Zengjun Xu
Cheng Wang
An Old Story with a New Twist: Do NMDARI mRNA Binding Proteins Regulate Expression of the NMDARI Receptor in the Presence of Alcohol?	311	(8)
Meena Kumari
Antje Anji
Antioxidative Effect of Vitamin D3 on Zinc-Induced Oxidative Stress in CNS.	319	(15)
Anya M. Y. Lin
K. B. Chen
P. L. Chao
Questions and Answers: Session VII	330	(4)
Session VIII. Mechanisms of Neuroprotection (2)
Antioxidant Effects of N-Acetylserotonin: Possible Mechanisms and Clinical Implications.	334	(14)
Gregory Oxenkrug
Novel Neuroprotective Mechanism of Action of Rasagiline Is Associated with Its Propargyl Moiety: Interaction of Bcl-2 Family Members with PKC Pathway.	348	(8)
Orly Weinreb
Tamar Amit
Orit Bar-Am
Orly Chillag-Talmor
Moussa B. H. Youdim
Gene Expression Profiling of Sporadic Parkinson's Disease Substantia Nigra Pars Compacta Reveals Impairment of Ubiquitin-Proteasome Subunits, SKPIA, Aldehyde Dehydrogenase, and Chaperone HSC-70.	356	(20)
Silvia Mandel
Edna Grunblatt
Peter Riederer
Ninette Amariglio
Jasmine Jacob Hirsch
Gideon Rechavi
Moussa B. H. Youdim
Neuronal Growth-Promoting and Inhibitory Cues in Neuroprotection and Neuroregeneration.	376	(10)
Stephen D. Skaper
Immune-Modulating Effects of Melatonin, N-Acetylserotonin, and N-Acetyldopamine.	386	(8)
Mary C. Perianayagam
Gregory F. Oxenkrug
Bertrand L. Jaber
N-Acetyldopamine Inhibits Rat Brain Lipid Peroxidation Induced by Lipopolysaccharide.	394	(6)
Gregory F. Oxenkrug
Pura J. Requintina
The In Vitro Effect of Estradiol and Testosterone on Iron-Induced Lipid Peroxidation in Rat Brain and Kidney Tissues.	400	(7)
Pura J. Requintina
Gregory F. Oxenkrug
Questions and Answers: Session VIII	405	(2)
Session IX. Sensitive Targets for Neurotoxicity and Neuroprotection
Neuroprotective Effects of Neurotrophins and Melanocortins in Spinal Cord Injury: An Experimental Study in the Rat Using Pharmacological and Morphological Approaches.	407	(15)
Hari Shanker Sharma
Neuroprotective Effects of Nitric Oxide Synthase Inhibitors in Spinal Cord Injury--Induced Pathophysiology and Motor Functions: An Experimental Study in the Rat.	422	(13)
Hari Shanker Sharma
Rajendra D. Badgaiyan
Per Alm
S. Mohanty
Lars Wiklund
Acrylamide Stimulates Glutamine Uptake in Fischer 344 Rat Astrocytes by a Mechanism Involving Upregulation of the Amino Acid Transport System N.	435	(9)
Qi Wu
Marta Sidoryk
Lysette Mutkus
Mugdalena Zielinska
Jan Albrecht
Michael Aschner
Effects of Acrylamide on Primary Neonatal Rat Astrocyte Functions.	444	(11)
Michael Aschner
Qi Wu
Marvin A. Friedman
Neuroprotection by Platelet-Activating Factor Antagonism.	455	(5)
Xiaohua Tian
Nicolas G. Bazan
Questions and Answers: Session IX	457	(3)
Session X. Novel Approaches to Neuroprotection
Expression of Prostaglandin E2 Synthases in Mouse Postnatal Cortical Neurons.	460	(12)
Valentina Echeverria
David L. Greenberg
Sylvain Dore
Novel Neuroprotective Tripeptides and Dipeptides.	472	(10)
Alan I. Faden
Susan M. Knoblach
Vilen A. Movsesyan
Paul M. Lea IV
Ibolja Cernak
Cocaine Induces a Differential Dose-Dependent Alteration in the Expression Profile of Immediate Early Genes, Transcription Factors, and Caspases in PC12 Cells: A Possible Mechanism of Neurotoxic Damage in Cocaine Addiction.	482	(9)
Syed Z. Imam
Helen M. Duhart
John T. Skinner
Syed F. Ali
Neuroprotection in the PNS: Erythropoietin and Immunophilin Ligands.	491	(14)
Ahmet Hoke
Sanjay C. Keswani
Questions and Answers: Session X	502	(3)
Session XI. Workshop PBPK/PD Models for Developing Humans: Risk Assessment Strategies and Research Recommendations
Improving Predictive Modeling in Pediatric Drug Development: Pharmacokinetics, Pharmacodynamics, and Mechanistic Modeling.	505	(14)
William Slikker Jr.
John F. Young
Richard A. Corley
David C. Dorman
Rory B. Conolly
Thomas B. Knudsen
Brian L. Erstad
Richard H. Luecke
Elaine M. Faustman
Charles Timchalk
Donald R. Mattison
Index of Contributors	519