This outstanding volume combines the two most pertinent lines of research on central nervous system deficits associated with chronic alcoholism: the biomedical measurement of brain structure and function, and the neuropsychological changes accompanying brain alterations. An effective presenter/discussant format is used by the diverse and distinguished international contributors who summarize the current state of knowledge in the field, critically evaluate the methods, identify the relevant variables in this type of research, and consider the implications for diagnosis and treatment.