Neurotherapy

by Verhaagen; Hol; Huitinga; Wijnholds; Bergen; Boer; Swaab

• ISBN13: 9780123745118
• ISBN10: 012374511X
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-10-16
• Publisher: Elsevier Science

Summary

This volume in the Progress in Brain Research series addresses the exciting recent progress in Restorative Neurology and Neuroscience with a focus on major neurodegenerative disorders of the brain and the visual system, including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, macula degeneration, retinitis pigmentosa, glaucoma, peripheral nerve and spinal cord trauma and multiple sclerosis.

Table of Contents

List of Contributors	p. v
Preface	p. ix
Acknowledgments	p. xi
Stem Cells
Cell transplantation strategies for retinal repair	p. 3
Strategies for retinal repair: cell replacement and regeneration	p. 23
The rostral migratory stream and olfactory system: smelt, disease and slippery cells	p. 33
Identifying and enumerating neural stem ceils: application to aging and cancer	p. 43
Transgenic reporter mice as tools for studies of transplantability and connectivity of dopamine neuron precursors in fetal tissue grafts	p. 53
Immunotherapy and Vaccination Therapy
Developing novel immunogens for a safe and effective Alzheimer's disease vaccine	p. 83
Innate immunity in the nervous system	p. 95
Neuroinnammation in spinal cord injury: therapeutic targets for neuroprotection and regeneration	p. 125
Toll-like receptors in the CNS: implications for neurodegeneration and repair	p. 139
Gene Therapy
Gene therapy and transplantation in the retinofugal pathway	p. 151
Controlled dissemination of AAV vectors in the primate brain	p. 163
From microsurgery to nanosurgery: how viral vectors may help repair the peripheral nerve	p. 173
Gene therapy for neurodegenerative diseases based on lentiviral vectors	p. 187
Trophic factors therapy in Parkinson's disease	p. 187
Pharmacotherapy
Progesterone as a neuroprotective factor in traumatic and ischemic brain injury	p. 219
Estrogen and testosterone therapies in multiple sclerosis	p. 239
Treatment of retinal diseases with VEGF antagonists	p. 253
Pharmacological modification of the extracellular matrix to promote regeneration of the injured brain and spinal cord	p. 269
The placebo response: neurobiological and clinical issues of neurological relevance	p. 283
Neuroprostheses
Brain-computer interfaces: an overview of the hardware to record neural signals from the cortex	p. 297
Artificial vision: needs, functioning, and testing of a retinal electronic prosthesis	p. 317
Progress in restoration of hearing with the auditory brainstem implant	p. 333
Microstimulation of visual cortex to restore vision	p. 347
Deep Brain Stimulation, FES and TMS
Functional neurosurgery for movement disorders: a historical perspective	p. 379
Recovery of control of posture and locomotion after a spinal cord injury: solutions staring us in the face	p. 393
Deep brain stimulation in obsessive-compulsive disorder	p. 419
The use of repetitive transcranial magnetic stimulation (rTMS) for the treatment of spasticity	p. 429
Mechanisms of Spontaneous Plasticity and Regeneration
Calcium signaling and the development of specific neuronal connections	p. 443
Remyelination in multiple sclerosis	p. 453
Magnetic resonance techniques to quantify tissue damage, tissue repair, and functional cortical reorganization in multiple sclerosis	p. 465
MRI of neuronal network structure, function, and plasticity	p. 483
The eighteenth C.U. Ariëns Kappers lecture: an introduction	p. 497
Molecular control of brain plasticity and repair	p. 501
Subject Index	p. 511
Table of Contents provided by Ingram. All Rights Reserved.