New Biocides Development The Combined Approach of Chemistry and Microbiology

by Zhu, Peter C.

• ISBN13: 9780841274051
• ISBN10: 0841274053
• Format: Hardcover
• Copyright: 2007-09-07
• Publisher: American Chemical Society

Summary

This book covers the latest progress on wide topics of biocides R&D: prioncides, biofilms, topical biocides, new biocides synthesis, mechanisms, structure-activity relationship, hospital and topical disinfection, biocides environmental effect, naturally occurring biocides, oxidizing biocides, aldehyde biocides, boron derivative biocides, traditional and non-classical biocides from most known researchers in the fields worldwide. The latest prion inactivation breakthrough discovery by Stanley B. Prusiner's group is also included. Historically, it was the interplay of chemistry and microbiology that helped to discover new biocides and new methods of disinfection. Tight integration of chemistry & microbiology for effective biocides discovery and development is the major theme of this book. This approach makes this book especially valuable for researchers and traditional practitioners alike in biocide field. Recent progress in both chemistry and life sciences has provided tremendous new opportunities to evaluate old and new biocides with new hopes.

Table of Contents

Preface	p. xi
General
Effects of Environmental Chemicals and the Host-Pathogen Relationship: Are There Any Negative Consequences for Human Health?	p. 2
Disinfection and Sterilization in Healthcare Facilities	p. 31
Prioncides
Disinfection of Prions	p. 52
Strategies for Inactivating Prions	p. 75
Biocides for Biofilms
Biofilms and Biocides: Growing Consistent Monoculture Biofilms for Biocide Assessment	p. 92
Topical Antimicrobials	p. 124
New Biocide Synthesis
Preparation of Phthalaldehydes by Hydrolysis of Aromatic gem-Tetrabromides	p. 152
Mechanisms and Structure-Activity Relationship
Efficacy and Mycobactericidal Action of Aldehydes: Structure-Activity Relationship	p. 162
ortho-Phthalaldehyde: Mechanisms of Action against Mycobacteria	p. 182
The Jekyll and Hyde Roles of Cysteine Derivatives during Oxidative Stress	p. 193
Identification Strategy of Mechanism-Based Lipophilic Antimicrobials	p. 213
Where Old Biocides Meet New Biocides: Hypohalite Defense Factors of the Human Oral Cavity	p. 269
Oxidizing Biocides
Peroxygens and Other Forms of Oxygen: Their Use for Effective Cleaning, Disinfection, and Sterilization	p. 292
Electrolyzed Water: Principles and Applications	p. 309
Use of Mannitol Hydrogen Peroxide to Control Microbial Produced Skin Irritants	p. 323
Micrology and Chemistry of ortho-Phthalaldehyde	p. 336
Aldehyde Biocides
Increasing Disinfection Efficacy of Glutaraldehyde via Chemical and Physical Enhancement	p. 348
Naturally Occurring Biocides
Natural Antimicrobials from Plant Essential Oils	p. 364
Antibacterial Actions of Ginkgolic Acids and Related Mechanisms	p. 389
Boron-Derivative Biocides
Antimicrobial Properties of Boron Derivatives	p. 412
Biocide Comparison Studies
Comparison of Mycobacterial Susceptibilities to Six Chemical Disinfectants	p. 438
A Comparison of the Microbicidal Efficacy on Germ Carriers of Several Tertiary Amine Compounds versus OPA and Perasafe	p. 451
Indexes
Author Index	p. 473
Subject Index	p. 475
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