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9783764358839

New Cytokines As Potential Drugs

by ;
  • ISBN13:

    9783764358839

  • ISBN10:

    3764358831

  • Format: Hardcover
  • Copyright: 2000-03-01
  • Publisher: Birkhauser

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Summary

Over the past ten years, a number of cytokines and growth factors have proven to be as effective therapeutics. While these products have certainly established recombinant biologics as a major pharmaceutical growth sector, the continued interest in this class of drugs arises from the fact that today we have a far better understanding of the human immune response, both at a cellular and molecular level. This has resulted in a more methodical characterisation of these factors which has given clinical researchers an opportunity to plan Phase 1 clinical trials that can provide substantial information on the activity of the cytokine in humans. Currently, a great deal of effort is also being channelled into identifying cytokines from the various DNA databases. Our major objective for this book is to profile cytokines that have been recently identified. The therapeutic potential of these cytokines based on their known properties will be discussed by the authors. The main aim of this book is to provide...

Table of Contents

List of contributors
vii
Preface ix
Interleukin 5
1(14)
Francis M. Cuss
Interleukin 10
15(16)
Satwant Narula
Sidney Smith
Paul Grint
Interleukin 16
31(22)
William W. Cruikshank
Hardy Kornfeld
David M. Center
Interleukin 17
53(6)
Francois Fossiez
Jean-Francois Nicolas
Serge Lebecque
Interleukin 18
59(22)
Masashi Kurimoto
FLT3 ligand
81(20)
Hilary J. McKenna
Keratinocyte growth factor-2
101(20)
Pablo A. Jimenez
Dale Greenwalt
Donna L. Mendrick
Mark A. Rampy
Jeffrey Su
Kam H. Leung
Kevin M. Connolly
Chemokines
121(18)
Sergio A. Lira
Paul J. Zavodny
Daniel Lundell
Index 139

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