New Generation Vaccines, Third Edition

by Levine, Myron M.; Kaper, James B.; Rappuoli, Rino; Liu, Margaret A.; Good, Michael F.

• ISBN13: 9780824740719
• ISBN10: 0824740718
• Edition: 3rd
• Format: Hardcover
• Copyright: 2004-01-28
• Publisher: Informa Healthc

Summary

Updated to reflect the wide spectrum of economic, regulatory, financial, ethical, and political issues impacting vaccinology in industrialized and developing nations, the Third Edition pinpoints relevant breakthroughs, trends, and advances that are altering the fields of vaccinology and immunization science-highlighting the most influential developments in vaccine safety, regulation, manufacture, and utilization, as well as clinical trials standardization and monitoring.

Table of Contents

Foreword
Preface to the Third Edition
Preface to the Second Edition
Vaccines and Vaccination in Historical Perspective	p. 1
An Overview of Biotechnology in Vaccine Development	p. 11
Initial Clinical Evaluation of New Vaccine Candidates: Investigators' Perspective of Phase I and II Clinical Trials of Safety, Immunogenicity, and Preliminary Efficacy	p. 19
Long-Term Evaluation of Vaccine Protection: Methodological Issues for Phase III and IV Studies	p. 29
Ethical Considerations in the Conduct of Vaccine Trials in Developing Countries	p. 49
Vaccine Economics: From Candidates to Commercialized Products in the Developing World	p. 57
Development and Supply of Vaccines: An Industry Perspective	p. 75
Reaching Every Child - Achieving Equity in Global Immunization	p. 89
A Paradigm for International Cooperation: The Global Alliance for Vaccines and Immunization (GAVI) and the Vaccine Fund	p. 101
Economic Analyses of Vaccines and Vaccination Programs	p. 107
The Role of the Food and Drug Administration in Vaccine Testing and Licensure	p. 117
Developing Safe Vaccines	p. 127
Polio Eradication: Capturing the Full Potential of a Vaccine	p. 145
Recent Advances in Immunology that Impact Vaccine Development	p. 159
High-Throughout Informatics and In Vitro Assays for T-Cell Epitope Determination: Application to the Design of Epitope-Driven Vaccines	p. 179
The Challenge of Inducing Protection in Very Young Infants	p. 197
Vaccination and Autoimmunity	p. 203
Adjuvants for the Future	p. 213
MF59 Adjuvant Emulsion	p. 225
Immune-Enhancing Sequences (CpG Motifs), Cytokines, and Other Immunomodulatory Moieties	p. 237
Use of Genetically Detoxified Mutants of Cholera and Escherichia coli Heat-Labile Enterotoxins as Mucosal Adjuvants	p. 251
Recent Developments in Vaccine Delivery Systems	p. 259
Proteosome Technology for Vaccines and Adjuvants	p. 271
Viruslike Particle (VLP) Vaccines	p. 283
Immunostimulating Reconstituted Influenza Virosomes	p. 295
Plants as a Production and Delivery Vehicle for Orally Delivered Subunit Vaccines	p. 305
Vaccinia Virus and Other Poxviruses as Live Vectors	p. 313
Live Adenovirus Recombinants as Vaccine Vectors	p. 325
RNA Virus Replicon Vaccines	p. 337
Attenuated Salmonella and Shigella as Live Vectors Carrying Either Prokaryotic or Eukaryotic Expression Systems	p. 353
DNA Vaccines	p. 367
DNA-Modified Virus Ankara and Other Heterologous Prime-Boost Immunization Strategies for Effector T Cell Induction	p. 381
Mucosal Immunization and Needle-Free Injection Devices	p. 393
Transcutaneous Immunization	p. 401
Combination Vaccines for Routine Infant Immunization	p. 413
Meningococcal Conjugate and Protein-Based Vaccines	p. 421
The Postlicensure Impact of Haemophilus influenzae Type b and Serogroup C Neisseria meningitides Conjugate Vaccines	p. 427
Pneumococcal Protein-Polysaccharide Conjugate Vaccines	p. 443
Pneumococcal Common Proteins and Other Vaccine Strategies	p. 459
Polysaccharide-Based Conjugate Vaccines for Enteric Bacterial Infections: Typhoid Fever, Nontyphoidal Salmonellosis, Shigellosis, Cholera, and Escherichia coli 0157	p. 471
Attenuated Strains of Salmonella enterica serovar Typhi as Live Oral Vaccines Against Typhoid Fever	p. 479
Vaccines Against Lyme Disease	p. 487
Oral B Subunit-Killed Whole-Cell Cholera Vaccine	p. 499
Attenuated Vibrio cholerae Strains as Live Oral Cholera Vaccines and Vectors	p. 511
Novel Vaccines Against Tuberculosis	p. 519
New Approaches to Influenza Vaccine	p. 537
Chimeric Vaccines Against Japanese Encephalitis, Dengue, and West Nile	p. 559
Challenges and Current Strategies in the Development of HIV/AIDS Vaccines	p. 573
Vaccine Strategies to Prevent Dengue Fever	p. 583
Vaccination Against the Hepatitis C Viruses	p. 593
Live Vaccine Strategies to Prevent Rotavirus Disease	p. 607
Vaccines Against Respiratory Syncytial Virus and Parainfluenza Virus Types 1-3	p. 621
Developing a Vaccine Against Epstein-Barr Virus	p. 641
Cytomegalovirus Vaccines	p. 649
Herpes Simplex Vaccines	p. 661
Vaccines for Hantaviruses, Lassa Virus, and Filoviruses	p. 679
Development of a Vaccine to Prevent Infection with Group A Streptococci and Rheumatic Fever	p. 695
Vaccines Against Group B Streptococcus	p. 711
Overview of Live Vaccine Strategies Against Shigella	p. 723
Oral Inactivated Whole Cell B Subunit Combination Vaccine Against Enterotoxigenic Escherichia coli	p. 737
Multivalent Shigella/Enterotoxigenic Escherichia coli Vaccine	p. 751
Vaccines Against Gonococcal Infection	p. 755
Vaccines Against Campylobacter jejuni	p. 775
Vaccines Against Uropathogenic Escherichia coli	p. 787
Vaccine Strategies Against Helicobacter pylori	p. 795
Vaccines for Staphylococcus aureus Infections	p. 807
Moraxella catarrhalis and Nontypable Haemophilus influenzae Vaccines to Prevent Otitis Media	p. 817
Vaccines for Chlamydia trachomatis and Chlamydia pneumoniae	p. 835
Overview of Vaccine Strategies for Malaria	p. 847
Adjuvanted RTS,S and Other Protein-Based Pre-Erythrocytic Stage Malaria Vaccines	p. 851
Malaria: A Complex Disease that May Require A Complex Vaccine	p. 861
Plasmodium falciparum Asexual Blood Stage Vaccine Candidates: Current Status	p. 875
Malaria Transmission-Blocking Vaccines	p. 887
Vaccines Against Leishmania	p. 903
Vaccines Against Schistosomiasis	p. 915
Vaccines Against Entamoeba histolytica	p. 927
Vaccines Against Human Hookworm Disease	p. 937
Principles of Therapeutic Vaccination for Viral and Nonviral Maligancies	p. 953
Vaccines Against Human Papillomavirus Infection	p. 977
Active Immunization with Dendritic Cells Bearing Melanoma Antigens	p. 987
Vaccine Against Alzheimer's Disease	p. 995
Vaccines Against Atherosclerosis	p. 1003
Vaccine Therapy	p. 1011
Vaccination-Based Therapies in Multiple Sclerosis	p. 1025
Vaccine Therapy for Autoimmune Diabetes	p. 1041
Vaccines for the Treatment of Autoimmune Diseases	p. 1047
Vaccines to Treat Drug Addiction	p. 1057
Vaccines Against Agents of Bioterrorism	p. 1067
A Primer on Large-Scale Manufacture of Modern Vaccines	p. 1081
Heterogeneity of Pediatric Immunization Schedules in Industrialized Countries	p. 1093
Index	p. 1097
Table of Contents provided by Blackwell. All Rights Reserved.