Nicotine Psychopharmacology

by Henningfield, Jack E.; London, Edythe D.; Pogun, Sakire; Ashley, D. L. (CON); Azizian, A. (CON)

• ISBN13: 9783540692461
• ISBN10: 3540692460
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-04-03
• Publisher: Springer Verlag

Summary

The field of nicotine psychopharmacology has rapidly expanded in recent years, driven by theoretical, pharmaceutical and tobacco-related interests. It was challenging to represent the many promising areas of research, from molecular to clinical to epidemiological, within a single volume. This book provides relatively focused reviews written by leading researchers on their areas of recent interest. Each article was reviewed by experts, producing a reference that will be useful to researchers, students, health professionals, and to the growing number of people involved in efforts to regulate tobacco product contents and designs nationally and internationally.

Table of Contents

Nicotine and Tobacco Consumption: Measurement and Trends
Global Patterns of Nicotine and Tobacco Consumption	p. 3
Nicotine Chemistry, Metabolism, Kinetics and Biomarkers	p. 29
Nicotine Content and Delivery Across Tobacco Products	p. 61
Nicotine Pharmacology and Mechanisms of Action
The Road to Discovery of Neuronal Nicotinic Cholinergic Receptor Subtypes	p. 85
Magnetic Resonance Imaging Studies of Cigarette Smoking	p. 113
In vivo Brain Imaging of Human Exposure to Nicotine and Tobacco	p. 145
Molecular and Cellular Mechanisms of Action of Nicotine in the CNS	p. 173
The Neuronal Pathways Mediating the Behavioral and Addictive Properties of Nicotine	p. 209
Molecular Genetics of Nicotine Metabolism	p. 235
Sex Differences in Nicotine Action	p. 261
Nicotine Psychopharmacology
Recognising Nicotine: The Neurobiological Basis of Nicotine Discrimination	p. 295
Effects of Nicotine in Experimental Animals and Humans: An Update on Addictive Properties	p. 335
Discriminative Stimulus Effects of Nicotine in Humans	p. 369
Rodent Models of Nicotine Withdrawal Syndrome	p. 401
Nicotine and Tobacco Product Regulation
Approaches, Challenges, and Experience in Assessing Free Nicotine	p. 437
Tobacco Industry Manipulation of Nicotine Dosing	p. 457
Pharmacotherapy for Tobacco Dependence	p. 487
Nicotine Psychopharmacology: Policy and Regulatory	p. 511
Index	p. 535
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