Nicotine Safety and Toxicity

by Benowitz, Neal L.

• ISBN13: 9780195114966
• ISBN10: 0195114965
• Format: Hardcover
• Copyright: 1998-08-27
• Publisher: Oxford University Press

Summary

Nicotine has been developed as a medication to assist smoking cessation, and is being considered as a possible drug for long-term maintenance of non-smoking. It is also undergoing evaluation as a possible treatment for several medical disorders, including ulcerative colitis, Alzheimer's disease, Parkinson's disease, Tourette's syndrome, attention deficit disorder, spasticity, and sleep apnea. Understanding its safety and toxicity is essential for drug developers, drug regulators, and clinicians making risk/benefit decisions about long-term nicotine therapy. Research on nicotine toxicity is also relevant to ongoing research on tobacco and health aimed at understanding the role of nicotine in contributing to tobacco-induced diseases. This book reviews the current scientific understanding of the safety and toxicity of nicotine. The discussion ranges from chemistry, studies in animals and human experimental research to the results of large clinical trials. Among the topics covered are cardiovascular disease, cancer, reproductive toxicity (including fetal toxicity and Sudden Infant Death Syndrome), behavioral toxicity (including abuse liability and addiction to nicotine medication), and gastrointestinal disease. Finally, contributions explore the risks and benefits of nicotine as a medication. The authors are world-renowned experts on their respective topics. No other book addresses nicotine toxicity in the depth or breadth of this volume. A book on the cutting edge of contemporary public health discourse, Nicotine Safety is an up-to-date and lucid overview of current knowledge on the subject. It will be a necessary addition to the bookshelves of clinicians with an interest in tobacco and health, drug developers and researchers, pharmacologists and toxicologists, public health researchers and policy-makers.

Table of Contents

Nicotine Pharmacology and Addiction

Nicotine and Cardiovascular Disease

Cardiovascular Toxicity of Nicotine: Pharmacokinetic and Pharmacodynamic Considerations

Cardiovascular Toxicity of Nicotine in Animals

Cardiovascular Effects of Cigarette Smoke and Snuff

Toxicity of Nicotine Replacement in Patients with Coronary Artery Disease

Nicotine and Cancer

The Metabolic Fate of (S)-Nicotine and its Pyrrolic Analog b-nicotyrine

Tobacco-Specific Nitrosamines

Nicotine and Lung Cancer

Nicotine and Reproduction

The Impact of Fetal Nicotine Exposure on Nervous System Development and Its Role in Sudden Infant Death Syndrome (SIDS)

Measuring Fetal Exposure to Nicotine, Gideon Koren, Chrisoula Eliopoulos

Human Studies of Nicotine Replacement During Pregnancy

Behavioral Toxicity of Nicotine

Abuse Liability of Nicotine

Table of Contents provided by Publisher. All Rights Reserved.