Nitric Oxide in Bone and Joint Disease

by Edited by Mika V. J. Hukkanen , Julia M. Polak , Sean P. F. Hughes

• ISBN13: 9780521175135
• ISBN10: 0521175135
• Edition: 1st
• Format: Paperback
• Copyright: 2011-03-03
• Publisher: Cambridge University Press

Summary

Nitric oxide research has emerged as one of the most important new areas in bone and joint diseases. This book is the first to bring together current knowledge on the actions of nitric oxide and its role in such common diseases as arthritis and osteoporosis. The volume introduces the basic biology and biochemistry of nitric oxide, the immune response, and bone biology. While doing so, it reviews in depth the facts we know today and the future promise of this exciting area of research. Throughout the book, the authors emphasize potential new treatments that exploit our understanding of the role of nitric oxide in bone and joint disease. This resource will give scientists and clinicians unique insight into this increasingly important area of research.

Table of Contents

Foreword

Nitric Oxide and Cytokines: An Introduction

A brief overview of the biology of nitric oxide

Nitric oxide and immune responses

Bone biology and pathophysiological mechanisms of bone disease

Nitric Oxide in Arthritis

Nitric oxide and blood flow in arthritis

Effects of nitric oxide synthase inhibitors in experimental models of arthritis

Nitric oxide and prostaglandin interactions in acute and chronic inflammation

Nitric oxide and cartilage matrix turnover

Nitric oxide production in human inflammatory arthritides

The complex influences of reactive oxygen species on rheumatoid erosions and synovitis

Nitric Oxide, Bone Cell Function and Osteoporosis

Nitric oxide and osteoblast function

Nitric oxide as a mediator of cytokine effects on bone

The osteoclast, bone homeostasis and postmenopausal osteoporosis

Nitric Oxide and Mechanical Factors

Modulation of bone blood flow by nitric oxide

Fluid shear stress

Mechanical strain-associated nitric oxide production by bone cells

The response of bone and bone cells to mechanical stimulation

Aseptic loosening of total hip prostheses

Index

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