Non Myeloablative Allogeneic Transplantation

by Bashey, Asad; Ball, Edward D.

• ISBN13: 9780792376460
• ISBN10: 0792376463
• Format: Hardcover
• Copyright: 2002-02-28
• Publisher: Kluwer Academic Pub

Summary

Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use. Non-Myeloablative Allogeneic Transplantation will provide both practitioners and academic clinicians with a better understanding of underlying concepts, current methodologies, and results obtained by the pioneering centers for this rapidly evolving field.

Table of Contents

Contributors	vii
Preface	ix
Development of allogeneic hematopoietic stem cell transplantation (HSCT)	1	(38)
Januario E. Castro
Edward D. Ball
Immunosuppression with limited toxicity: the characteristics of nucleoside analogs and anti-lymphocyte antibodies used in non-myeloablative hematopoietic cell transplantation	39	(12)
Asad Bashey
Mobilization of allogeneic peripheral blood progenitor cells	51	(28)
Ping Law
Thomas A. Lane
Non-myeloblative induction of mixed hematopoietic chimerism: application to transplantation tolerance and hematologic malignancies in experimental and clinical studies	79	(22)
Megan Sykes
Thomas R. Spitzer
Combined use of autografting and non-myeloablative allografting for the treatment of hematologic malignancies and metastatic breast cancer	101	(12)
Angelo M. Carella
Germana Beltrami
Enrica Lerma
Marina Cavaliere
Maria T. Corsetti
Non-myeloablative hematopoietic stem cell transplantation (NST) in the treatment of human malignancies: from animal models to clinical practice	113	(24)
Avichai Shimoni
Arnon Nagler
Non-myeloablative allogeneic hematopoietic transplantation and induction of graft-versus-malignancy	137	(12)
Issa Khouri
Sergio Giralt
Richard Champlin
Outpatient allografting in hematologic malignancies and nonmalignant disorders - applying lessons learned in the canine model to humans	149	(28)
Michael Maris
Rainer F. Storb
Non-myeloablative transplants for congenital diseases	177	(36)
Jody Donahue
Ewa Carrier
Index	213