The Non-Motor Symptoms Complex of Parkinson's Disease

by Chaudhuri, K Ray; Tolosa, Eduardo; Schapira, Anthony; Poewe, Werner

• ISBN13: 9780199237234
• ISBN10: 0199237239
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-08-10
• Publisher: Oxford University Press

Summary

Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's disease, which are poorly recognized and inadequately treated by clinicians. The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future. Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this book summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research.

Table of Contents

List of contributors	p. ix
What are the non-motor symptoms of Parkinson's disease?	p. 1
Non-motor symptoms and pre-motor diagnosis of Parkinson's disease	p. 7
Non-motor symptoms in the early motor stages of Parkinson's disease	p. 19
Non-motor symptoms in advanced Parkinson's disease	p. 37
Assessment tools for non-motor symptoms of Parkinson's disease	p. 47
Imaging non-motor aspects of Parkinson's disease	p. 59
Non-motor signs in genetic forms of Parkinson's disease	p. 73
Cognitive dysfunction of Parkinson's disease	p. 95
Depression, anxiety and apathy in Parkinson's disease	p. 107
Dementia in Parkinson's disease	p. 121
Fatigue in Parkinson's disease	p. 135
Psychosis in Parkinson's disease	p. 147
Neurobiology of sleep: the role of dopamine in Parkinson's disease	p. 165
REM sleep behaviour disorder in Parkinson's disease	p. 177
Parkinson's disease and restless legs syndrome	p. 195
Excessive daytime sleepiness in Parkinson's disease	p. 205
Bladder dysfunction in Parkinson's disease	p. 215
Sexuality in Parkinson's disease	p. 225
Gastrointestinal dysfunctions in Parkinson's disease	p. 241
Postural hypotension in Parkinson's disease	p. 255
Sialorrhoea in Parkinson's disease	p. 271
Olfaction in Parkinson's disease	p. 279
Chronic pain and Parkinson's disease	p. 287
Ophthalmological aspects of Parkinson's disease	p. 297
Non-motor symptoms and health-related quality of life	p. 309
Non-motor symptoms and co-morbidity in Parkinson's disease	p. 321
Non-motor symptoms of Parkinson's disease and the effects of deep brain stimulation	p. 339
Impulse dyscontrol and dopamine dysregulation syndrome	p. 353
Treatment-related non-motor symptoms in Parkinson's disease	p. 369
Index	p. 383
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