Nuclear Cardiac Imaging Principles and Applications

by Iskandrian, Ami S.; Verani, Mario S.

• ISBN13: 9780803600713
• ISBN10: 0803600712
• Edition: 2nd
• Format: Hardcover
• Copyright: 1996-06-01
• Publisher: Oxford University Press

Summary

This is a definitive edited work on the assessment of heart problems through nuclear imaging and exercise testing, now in its second edition. New imaging agents, the shift from planar to SPECT imaging, and greater computer capabilities are all reflected in this completely rewritten volume.Technical aspects are described when necessary.

Table of Contents

Radiopharmaceuticals, Dosimetry, and Tracer Kinetics	1	(28)
Part I: An Introduction to Nuclear Medicine	1	(4)
Part II: Production of Radionuclides and Radiopharmaceutical Dosimetry	5	(5)
Part III: Tracer Kinetics	10	(15)
Glossary	25	(4)
Instrumentation and Technical Considerations in Planar and SPECT Imaging	29	(17)
Imaging Systems	29	(4)
Quality Assurance in Cardiac Nuclear Imaging: Detection Efficiency or Sensitivity	33	(5)
Digital Computers	38	(1)
Applications of Computers in Nuclear Cardiology	39	(1)
Thallium 201 Planar Imaging Methodology	40	(1)
Technetium 99m Sestamibi Imaging Methodology	41	(2)
Technetium 99m Teboroxime Imaging Methodology	43	(1)
Principles of Single-Photon Emission Computed Tomography: Acquisition and Processing	43	(3)
Exercise Testing and Physiology	46	(27)
Exercise Physiology	46	(4)
Types of Exercise Tests	50	(1)
Exercise Protocols	50	(1)
General Considerations for Exercise Testing	51	(2)
Interpretation	53	(9)
Results of Exercise Testing	62	(11)
Exercise Perfusion Imaging in Coronary Artery Disease: Physiology and Diagnosis	73	(71)
Anatomic and Physiologic Basis of Cardiac Imaging	74	(2)
Methods for Assessing Coronary Blood Flow in Humans	76	(2)
Technical Aspects of Exercise Perfusion Scintigraphy	78	(3)
Indications for Exercise Perfusion Imaging	81	(1)
Diagnosis of CAD by Exercise Scintigraphy	82	(50)
Detection of Silent Myocardial Ischemia by Myocardial Perfusion Imaging	132	(12)
Radionuclide Angiography	144	(75)
Gated Versus First-Pass RNA	145	(2)
Ejection Fraction Reliability and Reproductivity	147	(10)
Peripheral Circulatory Dynamics	157	(1)
Diastolic LV Function	157	(10)
Exercise RNA	167	(21)
Effect of Drugs on Ventricular Function	188	(13)
Simultaneous Assessment of Myocardial Function and Perfusion	201	(18)
Pharmacologic Stress Testing and Other Alternative Techniques in the Diagnosis of Coronary Artery Disease	219	(23)
Pharmacologic ``Stress'' Myocardial Perfusion Scintigraphy	220	(14)
Pharmacologic Stress in Combination with Radionuclide Angiography	234	(2)
Atrial Pacing Stress as an Adjunct to Cardiac Radionuclide Imaging	236	(1)
Induction of Coronary Vasoconstriction in Combination with Myocardial Perfusion Scintigraphy	236	(1)
Cold Pressor Stress as an Adjunct to Myocardial Perfusion Scintigraphy	236	(6)
Risk Assessment	242	(37)
Background	242	(1)
Cardiac Events	243	(1)
Clinical Models in Risk Stratification	243	(1)
Risk Assessment in Patients with Silent Ischemia	244	(1)
Risk Assessment in Patients with Stable Symptoms: Use of Perfusion Imaging	245	(9)
Risk Assessment in Patients with Stable Symptoms: Use of Radionuclide Angiography	254	(3)
Risk Assessment After Coronary Artery Bypass Surgery and Coronary Angioplasty	257	(1)
Risk Assessment After Acute Myocardial Infarction	257	(11)
Risk Assessment in Patients with Unstable Angina	268	(1)
Risk Assessment Before Major Noncardiac Surgery	269	(10)
Nuclear Imaging After Coronary Revascularization	279	(26)
Myocardial Perfusion Imaging and Coronary Revascularization	279	(18)
Radionuclide Angiography and Coronary Revascularization	297	(4)
Use of Radionuclide Imaging in Risk Assessment After Coronary Artery Revascularization	301	(4)
Myocardial Viability	305	(22)
Hibernation and Stunning	305	(2)
Patient Selection for Viability Studies	307	(1)
Methods for Detection of Viability	308	(11)
Factors Affecting Recovery of LV Function	319	(2)
Summary and Perspectives	321	(6)
Scintigraphic Techniques in Acute Ischemic Syndromes	327	(30)
Infarct-Avid Imaging	327	(13)
Myocardial Perfusion Imaging in Acute Myocardial Infarction	340	(11)
Thallium 201 and Technetium 99m Sestamibi in Unstable Angina	351	(6)
Scintigraphic Imaging in Other Types of Heart Disease	357	(49)
Valvular Heart Disease	358	(15)
Hypertrophic Cardiomyopathy	373	(2)
Other Types of Cardiomyopathies	375	(2)
Pericardial Disease	377	(1)
Systemic Disorders	377	(5)
Congenital Heart Disease	382	(4)
Doxorubicin Cardiotoxicity	386	(1)
Radiation Therapy	387	(1)
Effect of Angiographic Contrast Medium	387	(1)
Effect of Intra-aortic Balloon Pumping and Support Devices	388	(1)
Tumors	389	(2)
Changes in Cardiac Rhythm or Conduction	391	(3)
Septic Shock	394	(1)
Miscellaneous Conditions	394	(12)
Other Nuclear Imaging Modalities	406	(15)
Single-Photon Metabolic Imaging	406	(4)
Tracers of Cardiac Innervation and Receptors	410	(3)
Clot Detection by Imaging Techniques	413	(1)
Indium 111-Labeled Lymphocyte Imaging to Detect Cardiac Rejection	413	(1)
Atherosclerosis Imaging	414	(1)
The Multiwire Gamma Camera	414	(3)
Imaging of Tracer-Labeled Ischemia or Hypoxia	417	(4)
Alternative Noninvasive Imaging Techniques: Which Test, When, and Why?	421	(10)
Comparison of Noninvasive Techniques	421	(3)
Diagnosis of CAD	424	(1)
Risk Assessment of Patients with CAD	424	(3)
Detection of CAD in Patients with Aortic Valve Disease or Hypertrophic Cardiomyopathy	427	(1)
Assessment of Cardiotoxicity	427	(1)
Detection of Left-to-Right Intracardiac Shunts	427	(1)
Detection and Quantitation of Valvular Regurgitation	427	(1)
Detection and Localization of Bypass Tracts in Patients with Wolff-Parkinson-White Syndrome	427	(1)
Assessment of LV Function and Right Ventricular Function	427	(1)
Cost-Effectiveness Analysis	427	(4)
Appendix A Laboratory Organization	431	(11)
Appendix B Specific Training Requirements for Nuclear Cardiology	442	(1)
Index	443