Nuclear Organization, Chromatin Structure, and Gene Expression

by van Driel, Roel; Otte, Arie P.

• ISBN13: 9780198549239
• ISBN10: 0198549237
• Format: Hardcover
• Copyright: 1998-01-08
• Publisher: Oxford University Press

Summary

This is one of the first books that focuses on emerging concepts about the role of the structure of chromatin, the organization of the genome, and the structure of the interphase nucleus in the control of gene expression in eukaryotes. The first section analyses the relationship between thedynamic chromatin structure at the nucleosome level and gene expression. Section two looks into higher order chromatin structure in relation to transcription. In section three the molecular basis of epigenetic phenomena, like X-chromosome inactivation is discussed, starting from our understanding ofchromatin structure. Together, these topics form the molecular basis for our understanding of cell differentiation, knowledge that is essential for the design of transgenic animals and plants and for gene therapy in humans. The book is of direct interest to students that are new in the field and toinvestigators in the area of biomolecular sciences, like developmental biology, biochemistry, cell biology, microbiology and genetics. Also, those working in applied fields of research, i.e biotechnology and biomedicine, will strongly benefit from this book. It will help them to understandfundamental problems in transgenics and gene therapy. Importantly, a variety of human disorders may turn out to be caused by genetic or somatic errors related to this level of gene control.

Table of Contents

The plate section falls between pages 178 and 179
List of contributors	vii	(4)
Introduction: general perspective and key questions	xi
Roel van Driel
Arie P. Otte
PART I: NUCLEOSOME DYNAMICS AND TRANSCRIPTION	3	(80)
1 Nucleosomes: dynamic repressors of transcription	3	(16)
Sari Pennings
Timothy E. O'Neill
Geert Meersseman
E. Morton Bradbury
2 Role of a positioned nucleosome in constitutive repression and hormone induction of the MMTV promoter	19	(21)
Miguel Beato
Reyes Candau
Sebastian Chavez
Christian Mows
Mathias Truss
3 Histone modification and transcriptional competence	40	(18)
Alan P. Wolffe
4 Mechanisms for alleviating chromatin-mediated repression of transcription	58	(25)
Janet Quinn
Craig L. Peterson
PART II: HIGHER ORDER STRUCTURE OF THE GENOME AND THE NUCLEUS	83	(102)
5 Chromatin domains and boundary elements	83	(16)
Victor G. Corces
Tatiana I. Gerasimova
6 Nuclear matrix-associated regions	99	(17)
M. E. Eva Luderus
Roel van Driel
7 The chicken lysozyme chromatin domain	116	(13)
Constanze Bonifer
Nicole Faust
Matthias C. Huber
Harald Saueressig
Albrecht E. Sippel
8 Locus control regions	129	(16)
Frank Grosveld
Peter Fraser
9 Interphase chromosome positions and structure during silencing, transcription and replication	145	(24)
Laura Manuelidis
10 Genes and transcripts in the interphase nucleus	169	(16)
David L. Spector
PART III: BIOLOGICAL STRUCTURE AND EPIGENETIC CONTROL OF GENE EXPRESSION	185	(106)
11 DNA methylation and genomic imprinting	185	(12)
Marisa S. Bartolomei
12 X chromosome inactivation and heritable chromatin structure	197	(26)
Arthur D. Riggs
Maty Hershkovitz
13 Drosophila heterochromatin: retreats for repeats	223	(13)
Amy K. Csink
Georgette L. Sass
Steven Henikoff
14 Mechanisms of heritable gene silencing during development of Drosophila	236	(14)
Achim Breiling
Renato Paro
15 Heterochromatin and regulation of gene expression in Saccharomyces cerevisiae	250	(26)
Miriam Braunstein
Scott G. Holmes
James R. Broach
16 Homology-dependent gene silencing in transgenic plants and related phenomena in other eukaryotes	276	(15)
Marjori A. Matzke
Antonius J. M. Matzke
Index	291