Nuclear Structure and Gene Expression

by Bird, R. Curtis; Stein, Gary S.; Lian, Jane B.; Stein, Janet L.

• ISBN13: 9780121001605
• ISBN10: 0121001601
• Format: Hardcover
• Copyright: 1997-01-01
• Publisher: Academic Pr

Summary

Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumor cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. Nuclear Structure and Gene Expression presents concepts as well as experimental approaches, which define functionality of nuclear morphology. * Mechanisms of interaction between nuclear structure and genes * Gene expression regulation by elements of the nuclear matrix * How nuclear structure exerts a regulatory effect on other aspects of cell function/physiology

Table of Contents

Introduction

The Nuclear Matrix: Past and Present

Nuclear Matrix Structure and Function

The Nuclear Matrix: Mapping Genomic Organization and Function in the Cell Nucleus

Composition and Structure of the Internal Nuclear Matrix

High Unwinding Capability of Matrix Attachment Regions and ATC-Sequence Context-Specific MAR-Binding Proteins

The Cyclin/Cyclin-Dependent Kinase Complex: Regulation of Cell Cycle Progression and Nuclear Disassembly

Chromatin Structure and Transcritpion Complexes

Nuclear Architecture in Developmental Transcriptional Control of Cell Growth and Tissue-Specific Genes

Transcription by RNA Polymerase II and Nuclear Architecture

Nuclear mRNP Complexes

Protein Disposition on Nascent Pre-mRNA Transcripts

Chapter References

Subject Index

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