Nucleic Acids in Chemistry and Biology

by Blackburn, G. Michael; Gait, Michael J.

• ISBN13: 9780199635344
• ISBN10: 019963534X
• Edition: 2nd
• Format: Hardcover
• Copyright: 1996-07-25
• Publisher: Oxford University Press

Summary

Since the discovery of the DNA double helix in 1953, nucleic acids haveformed the central theme of much of contemporary molecular science. Recentmastery of nucleic acids synthesis has been the key to the establishment of thebiotechnology industry, and our improving knowledge of nucleic acid structuresand interactions is considerably influencing the design of novel drugs.The first edition of this book responded to the pressing need for a singlevolume that integrated the chemistry and biology of the nucleic acids in anintroductory yet authoritative text. This second and completely updatededition, which includes a new chapter on techniques applied to nucleic acids,sets the basics of the nucleic acids in the context of the expanding horizonsset by modern structural biology, RNA enzymology, drug discovery andbiotechnology.

Table of Contents

Introduction and overview

DNA and RNA structure

Chemical synthesis

Biosynthesis of nucleotides

DNA sequence information, replication, and rearrangement

RNA sequence information and transmission

Covalent interactions of nucleic acids with small molecules

Reversible interactions of nucleic acids with small molecules

Interaction of proteins with nucleic acids

Techniques applied to nucleic acids

Glossary

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