Nucleic Acids in Chemistry and Biology

by Blackburn, G. Michael; Gait, Michael J.

• ISBN13: 9780199631216
• ISBN10: 0199631212
• Format: Paperback
• Copyright: 1991-02-21
• Publisher: Oxford University Press

Summary

This unique book takes a radically fresh approach in providing general information on the chemistry and biological activity of nucleic acids. The book is easily understood by those with a basic scientific background, and includes historical perspectives, an outline of essential features of DNA and RNA structure, and information on the chemical synthesis of biologically important nucleosides, nucleotides, and oligonucleotides. Nucleotide biosynthesis is crisply presented, as is the basic molecular biology of DNA and RNA. Recent exciting developments in RNA auto-catalysis are also featured. The final chapter contrasts the in vivo rearrangements that DNA can undergo wit the in vitro techniques of manipulation of DNA sequences in cloning mutagensis. Written from a chemical, structural, and molecular standing, this volume fills a longstanding need for a basic text on the nucleic acids.

Table of Contents

Introduction and Overview

DNA and RNA Structure

Chemical Synthesis

Biosynthesis of Nucleotides

DNA Sequence Information and Transmission

Covalent Interactions of Nucleic Acids with Small Molecules

Physical Interactions of Nucleic Acids with Small Molecules

Interactions of Nucleic Acids with Proteins

DNA Sequence Rearrangements and Alternations

Table of Contents provided by Publisher. All Rights Reserved.