The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Contributors to Volume 321

vii

Preface

ix

Volumes in Series

xi

Physiological Modeling with Virtual Cell Framework

1

(22)

James C. Schaff

Boris M. Slepchenko

Leslie M. Loew

Kinetic Analysis of Dynamics of Muscle Function

23

(15)

Julien S. Davis

Molecular Parameters from Sedimentation Velocity Experiments: Whole Boundary Fitting Using Approximate and Numerical Solutions of Lamm Equation

38

(28)

Borries Demeler

Joachim Behlke

Otto Ristau

Sedimentation Velocity Analysis of Macromolecular Assemblies

66

(15)

Lenny M. Carruthers

Virgil R. Schirf

Borries Demeler

Jeffrey C. Hansen

Analysis of Weight Average Sedimentation Velocity Data

81

(19)

John J. Correia

Sedimentation Equilibrium Analysis of Mixed Associations Using Numerical Constraints to Impose Mass or Signal Conservation

100

(21)

John S. Philo

Optimal Data Analysis Using Transmitted Light Intensities in Analytical Ultracentrifuge

121

(15)

Emilios K. Dimitriadis

Marc S. Lewis

Ultracentrifugal Analysis of Molecular Mass of Glycoproteins of Unknown or Ill-Defined Carbohydrate Composition

136

(13)

Marc S. Lewis

Richard P. Junghans

Irregularity and Asynchrony in Biologic Network Signals

149

(33)

Steven M. Pincus

Distribution Methods and Analysis of Nonlinear Longitudinal Data

182

(14)

Michelle Lampl

Michael L. Johnson

Distinguishing Models of Growth with Approximate Entropy

196

(11)

Michael L. Johnson

Michelle Lampl

Martin Straume

Approximate Entropy as Indication of Goodness of-Fit

207

(9)

Michael L. Johnson

Martin Straume

Kinetic Models and Data Analysis Methods for Fluorescence Anisotropy Decay

216

(23)

Edward L. Rachofsky

William R. Laws

Analysis of Nonequilibrium Facets of Pulsatile Sex-Steroid Secretion in Presence of Plasma-Binding Proteins

239

(24)

Johannes D. Veldhuis

Michael L. Johnson

Monte Carlo Simulations of Lateral Membrane Organization

263

(15)

Mads C. Sabra

Ole G. Mouritsen

Hydrodynamic Bead Modeling of Biological Macromolecules

278

(27)

Olwyn Byron

Bayesian Hierarchical Models

305

(25)

Christopher H. Schmid

Emery N. Brown

Monte Carlo Applications to Thermal and Chemical Denaturation Experiments of Nucleic Acids and Proteins

330

(23)

D. Jeremy Williams

Kathleen B. Hall

Analysis of Drug-DNA Binding Data

353

(16)

Xiaogang Qu

Jonathan B. Chaires

Neural Network Techniques for Informatics of Cancer Drug Discovery

369

(27)

William W. van Osdol

Timothy G. Myers

John N. Weinstein

Dynamic Network Model of Glucose Counterregulation in Subjects with Insulin-Requiring Diabetes

396

(14)

Boris P. Kovatchev

Martin Straume

Leon S. Farhy

Daniel J. Cox

Association of Self-Monitoring Blood Glucose Profiles with Glycosylated Hemoglobin in Patients with Insulin-Dependent Diabetes

410

(7)

Boris P. Kovatchev

Daniel J. Cox

Martin Straume

Leon S. Farhy

Outliers and Robust Parameter Estimation

417

(7)

Michael L. Johnson

Parameter Correlations while Curve Fitting

424

(23)

Michael L. Johnson

Author Index

447

(14)

Subject Index

461

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