Ocular Blood Flow and Glaucomatous Optic Neuropathy

by Mozaffarieh, Maneli; Flammer, Josef

• ISBN13: 9783540694427
• ISBN10: 3540694420
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-05-04
• Publisher: Springer Verlag

Summary

It has been suspected since more than a century that disturbed ocular blood flow (OBF) may play a role in the pathogenesis of glaucoma. Reduced OBF has been measured in glaucoma patients by numberless centres with different techniques in different tissues of the eye. And reduced OBF has been proven to be of prognostic value. Nevertheless the implementation of this knowledge into clinical practice has been very slow.This practical book will help many ophthalmologists to better understand glaucoma. The reading of this book will not only improve patient care but also give the reader intellectual satisfaction.

Table of Contents

Author biographies	p. vii
Preface	p. ix
Preface	p. xi
Acknowledgements	p. xiii
Abbreviations	p. xv
Introduction	p. 1
Basic sciences relevant to glaucoma	p. 5
What is a redox reaction?	p. 5
What is the role of light?	p. 6
The oxygen molecule	p. 7
The concept of cellular stress	p. 11
Oxidative stress	p. 13
Assessment of ocular blood flow	p. 15
What is glaucoma?	p. 27
Glaucomatous optic neuropathy	p. 27
Epidemiology of glaucoma	p. 28
Symptoms of chronic glaucoma	p. 28
Signs of glaucomatous optic neuropathy	p. 30
Risk factors for glaucoma	p. 35
Risk factors for an increase in intraocular pressure	p. 35
Risk factors for glaucomatous optic neuropathy	p. 36
The role of ocular blood flow	p. 40
Regulation of ocular blood flow	p. 45
Regulation of blood flow in the eye	p. 45
Endothelial-derived vasoactive factors	p. 48
Circulating hormones	p. 50
Vascular dysregulation syndrome	p. 55
What is vascular dysregulation?	p. 55
Primary vascular dysregulation	p. 55
Primary vascular dysregulation and other risk factors for glaucomatous optic neuropathy	p. 61
Primary vascular dysregulation and eye circulation	p. 63
Primary vascular dysregulation and other eye diseases	p. 64
Secondary vascular dysregulation	p. 66
Reperfusion damage	p. 69
What is reperfusion injury?	p. 69
What leads to reperfusion injury?	p. 69
Why does reperfusion injury induce glaucomatous optic neuropathy?	p. 70
Are there signs of oxidative stress in human glaucoma?	p. 71
Pathogenesis of glaucomatous optic neuropathy	p. 75
Treatment strategies	p. 79
Importance of reducing intraocular pressure	p. 79
Methods to reduce intraocular pressure	p. 79
Non-intraocular pressure lowering treatments	p. 80
Further reading	p. 99
Index	p. 101
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