Oogenesis : The Universal Process

Summary

Oogenesis - the process by which female germ cells develop into mature eggs, or ova - is a complex process involving many important elements of developmental and cellular biology: from cell-cell interactions, complex signalling cascades, specialized cell cycles and cytoskeleton organization. Oocytes from various species (including clam, starfish, xenopus and mouse) are excellent model systems to study the biochemistry of cell division with important implications for basic and clinical research.This book describes the entire process of oogenesis in chronological order with contributions from leading international researchers and chapters covering medical and ethical considerations in oogenic biology. Topics include sex determination and gonadal development, control of meiotic chromosome pairing and homologous recombination, control of meiotic divisions and the remodelling of the oocyte into a totipotent zygote as well as medically-assisted reproduction.This volume is an essential resource for all students, researchers and clinicians in developmental and reproductive biology.Key features: Reaches beyond the study of simply meiosis to cover all aspects of oogenesis Synthesizes recent advances in the field, drawing on studies from different model species Chapter sequence designed to follow the time line in vivo Written by an international panel of expert researchers

List of Contributors
Foreword
Oocyte Determination
The Sperm/Oocyte Decision, a C. elegans Perspective
Sex Determination and Gonadal Development
Clytia hemisphaerica: A Cnidarian Model for Studying Oogenesis
Oocyte Growth
Soma–Germline Interactions in the Ovary: an Evolutionary Perspective
Homologous Chromosome Pairing and Recombination
Homologous Chromosome Pairing and Synapsis during Oogenesis
Meiotic Recombination in Mammals
Meiosis Resumption
Initiation of the Meiotic Prophase-to-Metaphase Transition in Mammalian Oocytes
Oocyte-Specific Translational Control Mechanisms
MPF and the Control of Meiotic Divisions: Old Problems, New Concepts
The Cytological Events of Meiotic Divisions
Meiotic Spindle Assembly and Chromosome Segregation in Oocytes
Mechanisms of Asymmetric Division in Metazoan Meiosis
Biological Clocks Regulating Meiotic Divisions
The Control of the Metaphase-to-Anaphase Transition in Meiosis
Mechanisms Controlling Maintenance and Exit of the CSF Arrest
Cytostatic Arrest: Post-ovulation Arrest Until Fertilization in Metazoan Oocytes
Oocyte Ageing in Mammals
Mammalian Oocyte Population throughout Life
From Oocyte to Embryo
Fertilization and the Evolution of Animal Gamete Proteins
Remodelling the Oocyte into a Totipotent Zygote: Degradation of Maternal Products
Chromatin Remodelling in Mammalian Oocytes
Follicles and Medically Assisted Reproduction
Index
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