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9780191768736

Opioids in Cancer Pain

by ; ; ;
  • ISBN13:

    9780191768736

  • ISBN10:

    0191768731

  • Edition: 2nd
  • Format: eBook
  • Copyright: 2013-05-30
  • Publisher: Oxford University Press
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Author Biography


Mellar P. Davis, Director of Research, Harry R. Horvitz Center of Palliative Medicine, Taussig Cancer Center, Division of Solid Tumor, Cleveland Clinic, USA,Paul A. Glare, Chief, Pain and Palliative Care Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA,Janet Hardy, Director of Palliative Care, Mater Health Services, South Brisbane, Queensland, Australia,Columba Quigley, Formerly Consultant/Honorary Senior Lecturer in Palliative Medicine, Hammersmith Hospitals Trust, London, UK

Mel Davis is Director of Research at the Harry R. Horvitz Center of Palliative Medicine, Taussig Cancer Center, Division of Solid Tumor, Cleveland Clinic, USA. He also holds the positions of Editor-in-Chief of Progress in Palliative Care, and Chairman of the Palliative Section, Multinational Association of Supportive Care in Cancer. His research interests are in pain management, cancer pain, palliative medicine, symptom control and supportive cancer care.


Paul Glare is a Senior Staff Specialist Physician at Royal Prince Alfred Hospital (RPAH) in Sydney, Australia. He is Head of the Dept of Palliative Care at RPAH, and Head of Palliative Care Services for Sydney Cancer Centre and the eastern zone of Sydney South West Area Health Service (population 500,000). He is also Clinical Associate Professor of Medicine (Central Clincial School) at the University of Sydney.


Janet Hardy is the Director of Palliative Medicine for the Mater Health Services and is the Clinical Research Programme Leader for the Centre for Palliative Care Research and Education in Brisbane. She holds a chair in Palliative Medicine from the University of Queensland School of Medicine.


Columba Quigley previously held the post of Deputy Coordinating Editor of the Cochrane Collaboration Pain Palliative and Supportive Care Group. She has lectured and published in a range of areas, including opioid switching, alternative opioids, inter-individual variability in opioid responsiveness and the genetics of opioid response.

Table of Contents


1. Opioid receptors and opioid pharmacodynamics, Mellar P. Davis and Gavril W. Pasternak
2. Opioid pharmacokinetics, Kenneth C. Jackson, Mellar P. Davis & Columba Quigley
3. Liver disease and exogenous opioid pharmacokinetics, Mellar P. Davis
4. Opioids in renal failure, Janet Hardy & Columba Quigley
5. Codeine, Janet Hardy & Kenneth C. Jackson
6. Hydrocodone, Mellar P. Davis
7. Tramadol, Mellar P. Davis & Paul A. Glare
8. Dextropoxyphene, Paul A. Glare
9. Morphine, Paul A. Glare
10. Oxycodone, Paul A. Glare & Mellar P. Davis
11. The lipophilic opioids - fentanyl, alfentanil, sufentanil and remifentanil, Tony Hall & Janet Hardy
12. Buprenorphine, Mellar P. Davis
13. Methadone, Columba Quigley & Mellar P. Davis
14. Hydromorphone, Columba Quigley & Paul A. Glare
15. Levorphanol, Mellar P. Davis
16. Diamorphine, Janet Hardy & Columba Quigley
17. Oxymorphone, Paul A. Glare
18. Choice of opioids and the WHO ladder, Paul A. Glare
19. Pharmacogenetics and opioids, Joy Ross & Columba Quigley
20. Opioid rotation, Janet Hardy, Columba Quigley & Joy Ross
21. Equianalgesia, Mellar P. Davis & Kenneth C. Jackson
22. Dosing strategies for acute pain, Mellar P. Davis
23. Opioid dosing strategies for chronic pain and the management of opioid side effects, Mellar P. Davis
24. Patient controlled analgesia, Mellar P. Davis
25. Spinal opioids in cancer pain, Costantino Benedetti, Steven Paquelet & Mellar P. Davis
26. Opioid poorly responsive pain, physical dependence, tolerance and opioid-induced hyperalgesia, Mellar P. Davis
27. Opioids in special populations: developing countries, Mhoira Leng
28. Opioids in special populations: pediatric population, Ross Drake
29. Opioids in the terminal phase, Janet Hardy
30. Cancer pain and substance abuse, Kenneth L. Kirsh, Tatiana D. Starr, Lauren J. Rogak & Steven D. Passik

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