Opioids in Cancer Pain

by Davis, Mellar P.; Glare, Paul A.; Hardy, Janet; Quigley, Columba

• ISBN13: 9780199236640
• ISBN10: 019923664X
• Edition: 2nd
• Format: Hardcover
• Copyright: 2009-08-03
• Publisher: Oxford University Press

Summary

Cleveland Clinic Foundation, OH. Covers principles of opioid pharmacodynamics, pharmacokinetics, and pharmacogenetics; and discusses complex issues and debate surrounding the use of opioids. Features new chapters on opioids in pediatrics and developing countries. For clinicians. Previous edition: c2005.

Author Biography

Mel Davis is Director of Research at the Harry R. Horvitz Center of Palliative Medicine, Taussig Cancer Center, Division of Solid Tumor, Cleveland Clinic, USA. He also holds the positions of Editor-in-Chief of Progress in Palliative Care, and Chairman of the Palliative Section, Multinational Association of Supportive Care in Cancer. His research interests are in pain management, cancer pain, palliative medicine, symptom control and supportive cancer care.
Paul Glare is a Senior Staff Specialist Physician at Royal Prince Alfred Hospital (RPAH) in Sydney, Australia. He is Head of the Dept of Palliative Care at RPAH, and Head of Palliative Care Services for Sydney Cancer Centre and the eastern zone of Sydney South West Area Health Service (population 500,000). He is also Clinical Associate Professor of Medicine (Central Clincial School) at the University of Sydney.
Janet Hardy is the Director of Palliative Medicine for the Mater Health Services and is the Clinical Research Programme Leader for the Centre for Palliative Care Research and Education in Brisbane. She holds a chair in Palliative Medicine from the University of Queensland School of Medicine.
Columba Quigley previously held the post of Deputy Coordinating Editor of the Cochrane Collaboration Pain Palliative and Supportive Care Group. She has lectured and published in a range of areas, including opioid switching, alternative opioids, inter-individual variability in opioid responsiveness and the genetics of opioid response.

Table of Contents

Contributors	p. ix
List of abbreviations	p. xi
Opioid receptors and opioid pharmacodynamics	p. 1
Opioid pharmacokinetics	p. 29
Liver disease and exogenous opioid pharmacokinetics	p. 39
Opioids in renal failure	p. 69
Codeine	p. 81
Hydrocodone	p. 89
Tramadol	p. 99
Dextropropoxyphene	p. 119
Morphine	p. 127
Oxycodone	p. 155
The lipophilic opioids: fentanyl, alfentanil, sufentanil, and remifentanil	p. 175
Buprenorphine	p. 193
Methadone	p. 211
Hydromorphone	p. 245
Levorphanol	p. 253
Diamorphine	p. 263
Oxymorphone	p. 269
Choice of opioids and the WHO ladder	p. 275
Pharmacogenetics and opioids	p. 287
Opioid rotation	p. 301
Equi-analgesia	p. 313
Dosing strategies for acute pain	p. 329
Opioid dosing strategies for chronic pain and the management of opioid side effects	p. 347
Patient-controlled analgesia	p. 367
Spinal opioids in cancer pain	p. 385
Opioid poorly responsive pain, physical dependence, tolerance, and opioid-induced hyperalgesia	p. 403
Opioids in special populations: developing countries	p. 419
Opioids in special populations: paediatric population	p. 431
Opioids in the terminal phase	p. 455
Cancer pain and substance abuse	p. 461
Index	p. 479
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