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Preface | p. v |
Strategic Use of Preclinical Pharmacokinetic Studies and In Vitro Models in Optimizing ADME Properties of Lead Compounds | p. 1 |
Role of Mechanistic Transport Studies in Lead Optimization | p. 25 |
Metabolic Activation-Role in Toxicity and Idiosyncratic Reactions | p. 49 |
Case History - Use of ADME Studies for Optimization of Drug Candidates | p. 81 |
Solubility, Solubilization and Dissolution in Drug Delivery During Lead Optimization | p. 99 |
Lipid-based Systems, Drug Exposure and Lead Optimization | p. 131 |
Biopharmaceutics Modeling and the Role of Dose and Formulation on Oral Exposure | p. 151 |
Application of Physicochemical Data to Support Lead Optimization by Discovery Teams | p. 167 |
Computational Models Supporting Lead Optimization in Drug Discovery | p. 195 |
Prodrug Strategies for Improving Drug-Like Properties | p. 221 |
The Application of Multivariate Data Analysis to Compound Property Optimization | p. 243 |
Case History: Toxicology Biomarker Development Using Toxicogenomics | p. 255 |
Predicting Idiosyncratic Drug Reactions | p. 271 |
Elementary Predictive Toxicology for Advanced Applications | p. 301 |
The Application of PK/PD Modeling and Simulations During Lead Optimization | p. 323 |
Early Preclinical Evaluation of Brain Exposure in Support of Hit Identification and Lead Optimization | p. 355 |
Optimizing Biomarker Development for Clinical Studies at the Lead Optimization Stage of Drug Development | p. 411 |
The Relevance of Transporters in Determining Drug Disposition | p. 423 |
Index | p. 461 |
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