Oral Controlled Release Formulation Design and Drug Delivery Theory to Practice

by Wen, Hong; Park, Kinam

• ISBN13: 9780470253175
• ISBN10: 0470253177
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-10-19
• Publisher: Wiley
• More Book Details
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Summary

This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.

Author Biography

HONG WEN, PhD, is a Fellow and Project Leader in the Department of Pharmaceutical Development at Novartis, as well as a core member of the Novartis TRD S&T committee. He has contributed to dozens of INDs/IMPDs in addition to several approved NDAs. His expertise spans from discovery support and preformulation to late-phase development of solid dosage forms. He also specializes in bioavailability enhancement for water insoluble drugs, oral sustained release (SR) formulations, and combination products (FDC). He has written fifteen publications, six presentations, and eight patents in the drug delivery and controlled release fields.

KINAM PARK, PhD, is a Professor in the Department of Pharmaceutics and Showalter Distinguished Professor of Biomedical Engineering at Purdue University. He is also the President of Akina, Inc., specializing in drug delivery. Dr. Park is Editor-in-Chief of the Journal of Controlled Release among other journal and advisory board appointments. The recipient of the Controlled Release Society Founders Award in 2004, Dr. Park has published nine books, more than a hundred chapters, and more than two hundred journal articles, and holds sixteen patents.

Table of Contents

Preface

Introduction and Overview of Oral Controlled Release Formulation Design

Evolution of Oral Controlled Release Dosage Forms

Biopharmaceutic Consideration and Assessment for Oral Controlled Release (CR) Formulations

Preformulation Consideration for Drugs in Oral CR Formulation

Polymers used in Oral Modified Release Systems

Oral Extended Release Hydrophilic Matrices: Formulation and Design

Coating Systems for Oral Controlled-Release Formulations

Fluid Bed Coating and Granulation for CR Delivery

Controlled Release using Bilayer Osmotic Tablet Technology: Reducing Theory to Practice

Fast Disintegrating Tablets

Buccal Drug Delivery Systems

Oral Targeted Drug Delivery Systems: Gastric Retention Devices

Oral Targeted Drug Delivery Systems: Enteric Coating

Orally administered drug delivery systems to the colon

Dissolution Testing: In vitro Characterization of Oral Controlled Release Dosage Forms

Challenges and New Technologies of Oral Controlled Release

Oral Controlled Drug Delivery: Quality By Design approach to Drug Development

Oral Controlled Release-Based Products for Lifecycle Management

Generic Oral Controlled Release Product Development - Formulation and Process Considerations

The Science and Regulatory Perspectives of Emerging Controlled Release Dosage Forms

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