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9780824729455

Oral Lipid-Based Formulations: Enhancing the Bioavailability of Poorly Water-Soluble Drugs

by ;
  • ISBN13:

    9780824729455

  • ISBN10:

    0824729455

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2007-06-08
  • Publisher: CRC Press

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Summary

Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem of major significance, the pharmaceutical industry has been slow to apply and further develop this technology. This title provides a comprehensive summary of the theoretical and practical aspects of oral lipid-based formulations for use in industry and provides further insights into a developing technology expected to assume increasing prominence in years to come.

Table of Contents

Prefacep. vii
Contributorsp. xi
Currently Marketed Oral Lipid-Based Dosage Forms: Drug Products and Excipientsp. 1
Lipid-Based Excipients for Oral Drug Deliveryp. 33
Feasibility Assessment and Considerations for Scaling Initial Prototype Lipid-Based Formulations to Phase I/II Clinical Trial Batchesp. 63
Materials, Process, and Manufacturing Considerations for Lipid-Based Hard-Capsule Formatsp. 79
Liquid Self-Microemulsifying Drug Delivery Systemsp. 107
Lipid-Based Isotropic Solutions: Design Considerationsp. 129
Lipid-Based Self-Emulsifying Solid Dispersionsp. 149
Oral Lipid-Based Formulations: Using Preclinical Data to Dictate Formulation Strategies for Poorly Water-Soluble Drugsp. 185
Physiological Processes Governing the Gastrointestinal Absorption of Lipids and Lipophilic Xenobioticsp. 207
Characterizing Release from Lipid-Based Formulationsp. 241
Using In Vitro Dynamic Lipolysis Modeling as a Tool for Exploring IVIVC Relationships for Oral Lipid-Based Formulationsp. 257
Case Studies: Rational Development of Self-Emulsifying Formulations for Improving the Oral Bioavailability of Poorly Soluble, Lipophilic Drugsp. 273
Design and Development of Supersaturatable Self-Emulsifying Drug Delivery Systems for Enhancing the Gastrointestinal Absorption of Poorly Soluble Drugsp. 303
Indexp. 329
Table of Contents provided by Ingram. All Rights Reserved.

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