About the authors | |
Preface | |
Introduction to oral microbiology | |
Commensals and pathogens | |
Oral diseases | |
In the beginning | |
The first microbes | |
Microbial basis of infectious disease | |
Miller and the chemoparasitic theory of caries | |
Oral and dental research | |
Caries as an infectious disease | |
Dental caries as a transmissible disease | |
Streptococcus mutans | |
Mutans group streptococci | |
Link between S. mutans and dental caries | |
Immunity to caries | |
General properties of saliva | |
Saliva production | |
Protective role of saliva | |
Salivary pellicle | |
Saliva as a nutrient | |
Salivary mucins and agglutinins | |
Composition of mucins | |
Properties of mucins | |
Bacterial agglutination | |
Secretory Immunoglobulin A | |
Production of S-IgA | |
Functions of S-IgA | |
Inactivation of salivary defenses | |
Development of S-IgA | |
The window of infectivity | |
Selective IgA deficiency | |
Anti-microbial properties of saliva | |
Anti-microbial components in saliva | |
Innate defences | |
Anti-microbial peptides (AMPs) | |
Human AMPs | |
Microbes in the oral cavity | |
Primary colonizers | |
Beneficial effects of bacterial colonizers | |
Ecological plaque hypothesis | |
Ecology and disease | |
Molecular microbial taxonomy | |
Molecular taxonomy | |
Discontinuous gradient gel electrophoresis | |
DNA chips | |
Systems approaches to oral microbiology | |
Transcriptomics | |
Proteomics | |
Gene ontology | |
Post-translational networks | |
Tiled arrays | |
Oral streptococci | |
The genus Streptococcus | |
Viridans streptococci | |
Lancefield grouping | |
Relatedness and pathogenicity of streptococci | |
Microbial adherence | |
Adherence | |
Long-range adherence | |
Specific adhesion | |
Oral bacterial adhesins and receptors | |
Complex communities | |
Inter-microbial reactions | |
Co-adhesion | |
Metabolic associations | |
Antagonism | |
Biofilms | |
Biofilm development | |
Microbial recognition of surfaces and interbacterial communication | |
The biofilm matrix, resilience and resistance | |
Bacterial polysaccharides | |
Extracellular polysaccharide production | |
Glycosyltransferases and fructosyltransferases | |
Glucan binding proteins | |
EPS produced by oral Gram-negatives | |
Microbiology of caries | |
Structure of teeth | |
Dental caries | |
Types of dental caries | |
Important bacteria in caries | |
Emerging and polymicrobial pathogens | |
Virulence factors of S. mutans | |
Initial attachment to tooth surfaces | |
Polysaccharide production | |
Acid production | |
Acid tolerance | |
Biofilm adaptation | |
Host and environmental factors in caries | |
Host factors | |
Dietary factors | |
Caries risk assessment | |
Fluoride | |
Modes of action of fluoride | |
Strategies for fluoride delivery | |
Anti-microbial effects of fluoride | |
Enhancing anti-microbial effects | |
Anti-caries strategies | |
Inhibitors | |
Probiotics | |
Immunization | |
Vaccination | |
Periodontal diseases | |
Classification of periodontal diseases | |
Role of plaque bacteria in periodontal diseases | |
Role of host factors in periodontal diseases | |
Microorganisms associated with periodontal diseases | |
Gingivitis | |
Chronic periodontitis | |
Localized aggressive periodontitis | |
Generalized aggressive periodontitis | |
Color-coded complexes | |
P. gingivalis, a consensus pathogen | |
A. actinomycetemcomitans, a pathogen in LAP | |
Culture independent bacterial detection | |
Colonization by periodontal bacteria | |
Adhesion | |
Periodontal bacterial adhesins | |
Intracellular invasion | |
Mechanisms of invasion | |
Host responses to intracellular bacteria | |
Virulence factors of periodontal bacteria | |
Toxins | |
Proteolytic enzymes | |
Bacterial components that impact alveolar bone | |
Other toxic products | |
The immune response and periodontal bacteria | |
Importance of neutrophils | |
Innate immune sensing of periodontal bacteria | |
Tissue destruction and bone loss | |
Genetic factors associated with periodontal disease | |
Relationship between periodontal diseases and systemic health | |
Pathogenic mechanisms general principles | |
Cardiovascular disease (CVD) | |
Adverse pregnancy outcomes | |
Pulmonary infections | |
Diabetes | |
Osteoporosis | |
Implants and titanium | |
Osseo-integration | |
Implant structure | |
Peri-implantitis | |
Bacteria associated with peri-implantitis | |
Asepsis and treatment | |
Endodontic infections | |
Dentinal tubules | |
Bacterial invasion of dentin | |
Microbiota of endodontic infections | |
Symptomatic versus asymptomatic | |
Treatment | |
Host factors in endodontic infections | |
Pulpal infections | |
Periapical abscesses | |
Repair and angiogenesis | |
Resistant bacteria | |
Infective endocarditis | |
Bacteria in IE | |
Mechanism of vegetation formation | |
Bacterial virulence factors | |
Antibiotics in IE | |
Oral mucosal, bone and systemic infections | |
Mucosal infections | |
Submucosal and bone infections | |
Oral manifestations of systemic infections | |
Systemic manifestations of oral infections | |
Candida albicans and fungal infections | |
C. albicans | |
infections | |
Denture stomatitis | |
Angular cheilitis | |
Gingivitis and periodontal disease | |
Prosthetic implants | |
Biofilms and antifungal drugs | |
Oral virology I, herpes, papillomavirus and parvovirus | |
Herpes viruses | |
Papillomaviruses | |
Parvoviruses | |
Oral virology II, hepatitis and HIV | |
Hepatitis B virus (HBV) | |
Hepatitis D virus (HDV, delta agent) | |
Other hepatitis viruses | |
Human immunodeficiency virus (HIV) | |
Antibiotics and antibiotic resistance | |
Antibiotics in dentistry | |
Resistance to anti-microbial agents | |
Transfer of anti-microbial resistance | |
Curtailing anti-microbial resistance | |
Sterilization | |
Heat | |
Radiation | |
Chemicals | |
Disinfection | |
Physical | |
Chemical | |
Infection control | |
Prions | |
Dental unit water lines (DUWL) | |
Bioterrorism | |
Anthrax | |
Botulism | |
Smallpox | |
Salmonella | |
Biological weapons convention | |
Index | |
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