Oral Pharmacotherapy For Male Sexual Dysfunction

by Broderick, Gregory A.

• ISBN13: 9781588294517
• ISBN10: 158829451X
• Format: Hardcover
• Copyright: 2005-03-01
• Publisher: Humana Pr Inc

Summary

A state-of-the-art review of each aspect of male sexual dysfunction (interest, performance, and orgasm) and their implications for treatment. The authors address a wide variety of clinical issues, ranging from common medical risk factors for ED, to the evaluation and management of men who have atypical presentations that require focused testing; from diabetic ED to the safety assessment of PDE inhibitors for cardiac patients; and from combination drug therapy for refractory patients to neuropharmacological therapies. On the pharmaceutical side, the authors summarize the pharmacology and development of PDE-type 5 inhibitors, review the preclinical data and 5 years of postmarketing data on Viagra®, examine the preclinical data on Levitra®, and discuss the design and conduct of US clinical trials of Cialis®. Oral Pharmacology for Male Sexual Dysfunction: A Guide to Clinical Management clarifies for urologists, family physicians, and internists each of the diagnostic approaches to male sexual dysfunction, as well as the pharmacological strategies available for its safe and effective management.

Table of Contents

Preface	v
Contributors	xi
1 Physiology and Pharmacology of Erectile Dysfunction	1	(24)
Rafael Carrion, Derek Bochinski, Nadeem Rahman, and Tom F. Lue
2 Epidemiology of Erectile Dysfunction	25	(18)
Jonathan D. Schiff and John P. Mulhall
3 Pharmacology of Phosphodiesterase Inhibitors	43	(22)
Erwin Bischoff
4 Sildenafil Citrate, the Classical PDE5 Inhibitor: A Five-Year Review of its Efficacy and Safety in the Arena of Erectile Dysfunction	65	(20)
Harin Padma-Nathan
5 Tadalafil: Clinical Trials Experience	85	(24)
Culley C. Carson, III
6 Vardenafil: Clinical Trials Experience	109	(40)
Ajay Nehra
7 Erectile Dysfunction Assessment and Management in Primary Care Practice	149	(36)
Louis Kuritzky and Martin Miner
8 When to Refer the Patient With Erectile Dysfunction to a Specialist	185	(14)
Ira D. Sharlip
9 Erectile Dysfunction: Assessing Risk and Managing the Cardiac Patient	199	(22)
Thorsten Reffelmann and Robert A. Kloner
10 Is Diabetic Erectile Dysfunction More Difficult to Treat?	221	(16)
Pierre Theuma and Vivian A. Fonseca
11 Depression and Antidepressant-Associated Erectile Dysfunction	237	(16)
Raymond C. Rosen
12 Intracavernous, Transurethral, and Topical Therapies for Erectile Dysfunction in the Era of Oral Pharmacotherapy: Salvaging First-Line Therapy Failures With Combination Therapies	253	(26)
Hans-Martin A. Fritsche, Mustafa F. Usta, and Wayne J.G. Hellstrom
13 Androgen Deficiency of the Aging Male: Enhancing Erectile Response to Oral Pharmacotherapy	279	(22)
Alvaro Morales and Jeremy P.W. Heaton
14 Central Activation of Erection and Clinical Experience	301	(22)
Jeremy P.W. Heaton, Alvaro Morales, and Michael A. Adams
15 Sustaining the Cure: Oral Pharmacotherapy Failures Salvage With Vacuum Devices and Penile Implants	323	(16)
Ronald W. Lewis
16 Prevention and Treatment of Erectile Dysfunction Utilizing Lifestyle Changes and Dietary Supplements: What Works and What is Worthless?	339	(40)
Mark A. Moyad
17 Pharmacological Strategies in the Management of Rapid Ejaculation	379	(30)
Chris G. McMahon
18 Sexual Dysfunction After Radical Prostatectomy and the Use of PDE-5 Inhibitors	409	(14)
Andrew R. McCullough
19 Female Sexual Dysfunction: Is There a Magic Pill?	423	(22)
Ridwan Shabsigh, Anne R. Davis, Aristotelis G. Anastasiadis, Nawras Makhsida, and Grace Yan
Index	445