Organic Chemistry of Drug Design and Drug Action

by Silverman, Richard B

• ISBN13: 9780126437300
• ISBN10: 0126437300
• Edition: 1st
• Format: Hardcover
• Copyright: 1992-03-01
• Publisher: ACADEMIC PRESS INC

Summary

This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered! * Emphasizes the use of the principles of physical organic chemistry as a basis for drug design * Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes * Uses figures and literature references extensively throughout * This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications

Table of Contents

Preface

Introduction

Drug Discovery, Design, and Development

Receptors

Enzymes (Catalytic Receptors)

Enzyme Inhibition and Inactivation

DNA-Interactive Agents

Drug Metabolism

Prodrugs and Drug Delivery Systems

Index

Table of Contents provided by Publisher. All Rights Reserved.