Organic Synthesis on Solid Phase Supports, Linkers, Reactions

by Zaragoza Dö; rwald, Florencio

• ISBN13: 9783527306039
• ISBN10: 352730603X
• Edition: 2nd
• Format: Hardcover
• Copyright: 2002-10-22
• Publisher: Wiley-VCH

Summary

This is the number-one successful book on solid phase organic synthesis, now in its second, expanded edition. It offers the reader ? a comprehensive overview of supports, spacers, and linkers ? 15% more contents ? everything there is to know about reactions and their applications ? clear structure ? numerous experimental guidelines for use in practice The ideal reference for newcomers and experts. "... I have no doubts that this text will be the benchmark for future publications on the subject, and a very hard act to follow for authors planning books of their own on this red hot topic." The Alchemist

Author Biography

F. Zaragoza Dorwald studied chemistry at the Georg-August University of Gottingen and Universite Louis Pasteur, Strasbourg, where he obtained his Ph.D. in 1990 on the synthesis of natural products under the guidance of M. Franck-Neumann and M. Miesch. He spent each one postdoctoral year in the groups of A. Pfaltz (University of Basel) and A.P. Marchand (University of North Texas), and worked then on the synthesis of unnatural amino acids at the Technical University of Dresden. Since 1995 he has a position as medicinal chemist at Novo Nordisk A/S, M?l?v, Denmark. His main interests are the development of parallel and solid-phase syntheses for lead identification and optimization.

Table of Contents

Glossary and Abbreviations.

Experimental Procedures.

General Techniques and Analytical Tools for Solid-Phase Organic Synthesis.

Supports for Solid-Phase Organic Synthesis.

Linkers for Solid-Phase Organic Synthesis.

Preparation of Organometallic Compounds.

Preparation of Hydrocarbons.

Preparation of Alkyl and Aryl Halides.

Preparation of Alcohols and Ethers.

Preparation of Sulfur Compounds.

Preparation of Organoselenium Compounds.

Preparation of Nitrogen Compounds.

Preparation of Phosphorus Compounds.

Preparation of Aldehydes and Ketones.

Preparation of Carboxylic Acid Derivatives.

Preparation of Carbonic Acid Derivatives.

Preparation of Heterocycles.

Preparation of Oligomeric Compounds.

Index.