Osteoporosis

Summary

Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up to $18 billion each year. NEW TO THIS EDITION: *Recognizes the critical importance of the Wnt signaling pathway for bone health *Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone *Examines essential updates on estrogen prevention and treatment and the recent results from the WHI *Discusses the controversial topics of screening and clinical trial design for drug registration *Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone * Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics comprising a tremendous wealth of knowledge in a single source not found elsewhere

Introduction
The Bone Organ System: Form and Function
The Nature of Osteoporosis
The Economics of Osteoporosis
Reflections on Osteoporosis
Skeletal Heterogeneity and the Purposes of Bone Remodeling
Implications for the Understanding of Osteoporosis
Basic Science/Bone Biology Osteoblast
Biology Osteoclast
Biology Osteocytes
The Regulatory Role of Matrix
Proteins in Mineralization of Bone
Development of the Skeleton Mouse
Genetics as a Tool to Study Bone
Development and Physiology Parathyroid
Hormone and Parathyroid Hormone-Related
Protein
Vitamin D: Biology, Action, and Clinical Implications
Regulation of Bone Cell Function by Estrogens
Androgens and Skeletal Biology: Basic Mechanisms
Phosphatonins Wnt Signaling in Bone Cytokines and Bone
Remodeling Skeletal Growth Factors
Intercellular Communication During Bone
Remodeling Structural and Biomechanics Skeletal
Development: Mechanical Consequences of Growth, Aging and Disease
Inhibition of Osteoporosis by Biophysical
Intervention Biomechanics of Age-Related
Fractures Bone
Quality Epidemiology & Risk Factors
Epidemiologic Methods in Studies of Osteoporosis Race, Ethnicity and Osteoporosis
The Study of Osteoporotic Fractures (SOF): Major Findings and Contributions Bone
Mineral Acquisition in Utero and During Infancy and Childhood Bone
Acquisition in Adolescence Genetic
Determinants of Osteoporosis
Nutrition and Risk for Osteoporosis
Physical Activity in Prevention of Osteoporosis and Associated Fractures
Premenopausal Reproductive and Hormonal
Characteristics and the Risk for Osteoporosis
Non-Skeletal Risk Factors for Osteoporosis and Fractures
Falls as Risk Factors for Fracture Assessment of Fracture
Risk Outcomes of Osteoporotic Fractures
Pathophysiology Local and Systemic Factors in the Pathogenesis of Osteoporosis
Animal Models for Osteoporosis Estrogen, Bone
Homeostasis and Osteoporosis
Postmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone
Loss Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical Characterization
Osteoporosis in Childhood and Adolescence
Glucocorticoid-Induced Osteoporosis
Adult Scoliosis, Degenerative Disease, and BMD: a Sub-Segmental Analytic
Approach Mechanisms of Immobilization-induced Bone
Loss Leptin-Dependent Regulation of Bone
Mass Thyroid Hormone and the Skeleton
Osteoporosis in Gastrointestinal, Pancreatic, and Hepatic Disease
The Skeletal Actions of Parathyroid
Hormone in Primary Hyperparathyroidism and in Osteoporosis
Osteogenesis Imperfecta and Other Defects of Bone
Development as Occasional Causes of Adult Osteoporosis
Osteoporosis Associated with Illnesses and Medications
Transplantation Osteoporosis
Osteoporosis Associated with Cancer
Therapy Osteoporosis
Associated with Pregnancy Osteoporosis
Associated with Rheumatologic
Disease Oral Bone
Loss and Systemic Osteopenia: Potential Treatment and Risks Localized Osteoporosis
Evaluation and Management
Evaluation of the Patient with Osteoporosis or at Risk for Osteoporosis
Who Should be Screened: Who Should be Treated?
Radiology of Osteoporosis
Clinical Use of Bone Densitometry
Biochemical Markers of Bone Turnover in Osteoporosis
The Conundrum of Compliance and Persistence with Oral
Bisphosphonates for Postmenopausal Osteoporosis
An Orthopedic Perspective of Osteoporosis
Lessons from Bone Histomorphometry on the Mechanism of Action of Osteoporosis
Drugs Pharmacology and Therapeutics Design
Considerations for Clinical Investigations of Osteoporosis
Regulatory Considerations for the Design and Conduct of Osteoporosis
Registration Trials Ev
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