Oxidative Stress in Aging

by Miwa, Satomi

• ISBN13: 9781588299918
• ISBN10: 1588299910
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-08-30
• Publisher: Humana Pr Inc

Summary

Oxidative Stress in Aging: From Model Systems to Human Diseases tackles the question that Denham Harman posed so long ago: are oxygen free radicals at the root of aging? The current state of the answer is provided by critical in-depth analyses by leaders in the field and is hierarchically structured by model organism (yeast, worms, flies), culminating in an appraisal of the role of oxygen free radicals in the pathogenesis of age-related human diseases. Offers a state-of-the-art overview of the free radical theory of aging and oxidative biochemistry, Evaluates the role of oxidative stress in lifespan determination in different model organisms, Discusses the connection between free radicals, various diseases, and age-related pathological conditions, Reviews major interventions trials of antioxidant supplements in age-related diseases Book jacket.

Table of Contents

Preface	p. v
Contributors	p. xi
Introduction
Introduction	p. 3
The Basics of Oxidative Biochemistry	p. 11
The Role of Oxidative Stress in Aging
Different Model Systems
Retrograde Response, Oxidative Stress, and Cellular Senescence	p. 39
Reactive Oxygen Species in Molecular Pathways Controlling Aging in the Filamentous Fungus Podospora anserina	p. 53
Oxidative Stress and Aging in the Budding Yeast Saccharomyces cerevisiae	p. 67
Oxidative Stress and Aging in the Nematode Caenorhabditis elegans	p. 81
Roles of Oxidative Stress in the Aging Process of Drosophila melanogaster	p. 111
Does Oxidative Stress Limit Mouse Life Span?	p. 129
The Comparative Approach
Mitochondrial Free Radical Production and Caloric Restriction: Implications in Vertebrate Longevity and Aging	p. 149
Oxidative Stress in Human Aging and Diseases
Deregulation of Mitochondrial Function: A Potential Common Theme for Cardiovascular Disease Development	p. 165
Oxidative Stress in Type 2 Diabetes Mellitus	p. 191
DNA Oxidative Damage and Cancer	p. 213
Oxidative Stress in Hypertension	p. 229
Aging and Cardiac Ischemia-Mitochondria and Free Radical Considerations	p. 253
Role of the Antioxidant Network in the Prevention of Age-Related Diseases	p. 269
Future
Reactive Oxygen Species as Signaling Molecules	p. 293
Summary and Outlook	p. 309
Index	p. 313
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