Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome

by Sies; Helmut

• ISBN13: 9781420043785
• ISBN10: 1420043781
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-07-27
• Publisher: CRC Press

Summary

This groundbreaking work encourages the exploration and development of evidence-based nutritional and pharmacological therapies. It is hoped that these therapies will attenuate the impact of obesity-induced insulin resistance and ensuing metabolic syndrome. The book offers readers a greater understanding of the molecular mechanisms that underlie inflammation and oxidative stress. Edited by two of the world's leading authorities on oxidative stress, the book reporst on cutting-edge research that explores the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes in obesity and type 2 diabetes. It also brings together research on the molecular mechanisms inherent in the progression of metabolic stress, and includes phenotypic perspectives, while also discussing the role of dietary factors, including the importance of micronutrients..

Table of Contents

Series Preface	p. xi
Preface	p. xv
About the Editors	p. xvii
Contributors	p. xix
Oxidative Stress, Metabolic Syndrome, Obesity, Diabetes, and Uncoupling Proteins
The Metabolic Syndrome Defined	p. 3
The Metabolic Syndrome: The Question of Balance between the Pro-Inflammatory Effect of Macronutrients and the Anti-Inflammatory Effect of Insulin	p. 15
The Role of Oxidative Stress in Diseases Associated with Overweight and Obesity	p. 33
Metabolic Syndrome Due to Early Life Nutritional Modifications	p. 47
Oxidative Stress and Antioxidants in the Perinatal Period	p. 71
Maternal Obesity, Glucose Intolerance, and Inflammation in Pregnancy	p. 93
Obesity, Nutrigenomics, Metabolic Syndrome, and Type 2 Diabetes	p. 107
Post-Prandial Endothelial Dysfunction, Oxidative Stress, and Inflammation in Type 2 Diabetes	p. 123
Obesity and Inflammation: Implications for Atherosclerosis	p. 139
Oligomeric Composition of Adiponectin and Obesity	p. 167
Insulin-Stimulated Reactive Oxygen Species and Insulin Signal Transduction	p. 177
Intracellular Signaling Pathways and Peroxisome Proliferator-Activated Receptors in Vascular Health in Hypertension and in Diabetes	p. 195
Role of Uncoupling Protein 2 in Pancreatic ß Cell Function: Secretion and Survival	p. 211
Influence of Dietary Factors, Micronutrients, and Metabolism
Nutritional Modulation of Inflammation in Metabolic Syndrome	p. 227
Dietary Fatty Acids and Metabolic Syndrome	p. 243
Lipid-Induced Death of Macrophages: Implication for Destabilization of Atherosclerotic Plaques	p. 251
¿-Lipoic Acid Prevents Diabetes Mellitus and Endothelial Dysfunction in Diabetes-Prone Obese Rats	p. 261
Lipoic Acid Blocks Obesity through Reduced Food Intake, Enhanced Energy Expenditure, and Inhibited Adipocyte Differentiation	p. 273
Effects of Conjugated Linoleic Acid and Lipoic Acid on Insulin Action in Insulin-Resistant Obese Zucker Rats	p. 289
Trivalent Chromium Supplementation Inhibits Oxidative Stress, Protein Glycosylation, and Vascular Inflammation in High Glucose-Exposed Human Erythrocytes and Monocytes	p. 301
Index	p. 315
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