Pancreatic Cancer

by Evans, Douglas B., M.D.; Abbruzzese, James L.; Pisters, Peter W. T.

• ISBN13: 9780387951850
• ISBN10: 0387951857
• Format: Hardcover
• Copyright: 2001-09-01
• Publisher: Springer Verlag

Summary

The MD Anderson Solid Tumor Oncology series presents the most cutting-edge surgical treatment and medical therapy for specific sites. Each year, more than 26,000 people are diagnosed with pancreatic cancer, also called a "silent" disease because it does not usually exhibit early symptoms. This volume defines the current standard on multimodality care: surgery, chemotherapy, immunotherapy, gene therapy, radiotherapy, and a review of the latest research and clinical trials. It includes sections on: epidemiology/molecular biology, inherited pancreatic cancer syndromes, staging, various surgical techniques and outcomes, multimodality therapy and emerging and future therapies. The individual chapters focus on specific topics to produce a reference work of value to those interested in pancreatic cancer from a clinical and translational research perspective. A must-have for surgical oncologists and general surgeons.

Table of Contents

Series Preface	vii
Preface	ix
Contributors	xv
Part I Epidemiology/Molecular Biology	1	(82)
Molecular Epidemiology	3	(12)
Donghui Li
The Molecular Biology of Pancreatic Cancer	15	(14)
Marina E. Jean
Andrew M. Lowy
Paul J. Chiao
Douglas B. Evans
Molecular Markers as a Tool for the Early Diagnosis of Pancreatic Cancer	29	(18)
James R. Howe
Cell Signaling Pathways in Pancreatic Cancer	47	(16)
Jason B. Fleming
Epithelial Stem Cells in Pancreatic Regeneration and Neoplasia	63	(10)
Ingrid M. Meszoely
Anna L. Means
Charles R. Scoggins
Steven D. Leach
Inherited Pancreatic Cancer Syndromes	73	(10)
David H. Berger
William E. Fisher
Part II Staging	83	(40)
Pancreatic Cancer: Radiologic Staging	85	(12)
Harmeet Kaur
Evelyne M. Loyer
Elizabeth A. Lano
Chusilp Charnsangavej
Endoscopic Diagnosis and Staging: Endoscopic Ultrasound, Endoscopic Retrograde Cholangiopancreatography	97	(18)
Richard A. Erickson
Laparoscopic Staging	115	(8)
H. J. Kim
K. C. Conlon
Part III Surgery/Therapeutic Endoscopy/Pain Management	123	(110)
Whipple Procedure: 1935 to Present	125	(14)
Richard D. Schulick
Charles J. Yeo
Regional Lymph Node Dissection for Pancreatic Adenocarcinoma	139	(14)
Peter W.T. Pisters
Murray F. Brennan
Pylorus Preservation versus Standard Pancreaticoduodenectomy: Oncologic Controversies	153	(8)
Karen E. Todd
Howard A. Reber
Vascular Resection and Reconstruction for Localized Pancreatic Cancer	161	(10)
Charles R. Scoggins
Ingrid M. Meszoely
Steven D. Leach
A. Scott Pearson
Techniques for Biliary and Pancreatic Reconstruction After Pancreaticoduodenectomy	171	(10)
Jeffrey A. Drebin
Steven M. Strasberg
Transduodenal Local Resection for Periampullary Neoplasms	181	(12)
Bryan Clary
Theodore N. Pappas
Douglas Tyler
Distal Pancreatectomy for Pancreatic Cancer	193	(8)
Gulam Abbas
Gary R. Gecelter
Risks of Perioperative Mortality with Pancreaticoduodenectomy	201	(12)
Laura A. Lambert
John D. Birkmeyer
Endoscopic Palliation for Locally Advanced and Metastatic Disease: Biliary and Duodenal Stents	213	(10)
Kiranpreet S. Parmar
Irving Waxman
Celiac Plexus Block versus Systemic Opioid Medication in the Management of Pancreatic Cancer Pain	223	(10)
Suresh K. Reddy
Lurry L. Zhou
Part IV Multimodality Therapy	233	(88)
Postoperative Adjuvant Therapy: Past, Present, and Future Trial Development	235	(8)
William F. Regine
Preoperative (Neoadjuvant) Therapy for Resectable Adenocarcinoma of the Pancreas	243	(12)
Wayne A.I. Frederick
Robert A. Wolff
Christopher H. Crane
Jeffrey E. Lee
Peter W.T. Pisters
Douglas B. Evans
European Adjuvant Trials	255	(32)
Paula Ghaneh
David Smith
Jennifer Almond
Deborah Moffitt
Janet Dunn
John Slavin
Robert Sutton
Claudio Bassi
Paolo Pederzoli
Hans G. Beger
Karl H. Link
Helmut Freiss
Markus Buchler
John P. Neoptolemos
Adjuvant Regional Infusion Therapy
Two-Channel Chemotherapy to Prevent Hepatic Metastasis After Extended Pancreatectomy for Adenocarcinoma of the Pancreas: The Osaka Experience	269	(6)
Osamu Ishikawa
Hiroaki Ohigashi
Terumasa Yamada
Yo Sasaki
Masao Kameyama
Masahiro Hiratsuka
Toshiyuki Kabuto
Shingi Imaoka
Adjuvant Intra-arterial Chemotherapy With and Without Radiation Therapy in Pancreatic Cancer: The Ulm Experience	275	(5)
Frank Gansauge
Karl H. Link
Andrea Formentini
Miriam Schatz
Erwin Rottinger
Johannes Gorich
Hans G. Beger
Locoregional Targeting Immunochemotherapy for Resectable and Unresectable Pancreatic Head Carcinoma: The Athens Experience	280	(7)
Nikolaos J. Lygidakis
Labros Vlachos
Sotirios Raptis
George Rassidakis
Christos Kittas
Intraoperative Radiation for Pancreatic Cancer	287	(8)
Nora A. Janjan
Christopher H. Crane
Conformal Radiation Therapy in Pancreatic Cancer	295	(6)
Christopher H. Crane
Nora A. Janjan
Radiation Sensitizers, Fractionation Schedules, and Future Clinical Trials	301	(10)
A. William Blackstock
Cytotoxic Chemotherapy for Pancreatic Cancer: Past, Present, and Future	311	(10)
Robert A. Wolff
Part V Emerging Therapies	321	(86)
Animal Models of Pancreatic Adenocarcinoma	323	(8)
Ramon E. Jimenez
Andrew L. Warshaw
Carlos Fernandez-del Castillo
Strategies for Gene Therapy	331	(12)
Eugene A. Choi
Francis R. Spitz
Photodynamic Therapy and Endoscopic Ultrasound-Guided Therapy for Pancreatic Cancer	343	(4)
Sandeep Lahoti
Vaccine Therapy for Pancreatic Cancer	347	(10)
Eileen M. O'Reilly
Antiangiogenic Strategies in Pancreatic Cancer	357	(12)
Christiane J. Bruns
Lee M. Ellis
Robert Radinsky
Role of Matrix Metalloproteinase Inhibition in the Treatment of Pancreatic Cancer	369	(8)
Alexander S. Rosemurgy II
Mahmudul Haq
Regulation of Pancreatic Cancer Growth by Gastrointestinal Hormones: A Clinically Useful Strategy?	377	(12)
William E. Fisher
David H. Berger
Farnesyltransferase Inhibitors: Biological Considerations for Future Therapeutics	389	(8)
Adrienne D. Cox
L. Gerard Toussaint, III
Novel Therapeutic Targets for Drug Development	397	(10)
Daniel D. Von Hoff
Elizabeth R. Campbell
David J. Bearss
Index	407