Parkinsonian Disorders in Clinical Practice

by Schapira, Anthony; Hartmann, Andreas; Agid, Yves

• ISBN13: 9781405196017
• ISBN10: 1405196017
• Edition: 1st
• Format: Paperback
• Copyright: 2009-05-26
• Publisher: Wiley-Blackwell

Summary

This book gives the reader an up-to-date, clear and logical idea of what caring for parkinsonian patients entails - a challenge that clinicians will face for many years to come. It is split into three sections:Section 1: A compilation of the major brain lesions typically seen in PDSection 2: Treatment options in PDSection 3: 25 cases designed to test the reader and the practical application of the information supplied in the other sections.

Author Biography

Anthony HV Schapira, MD DSC, FRCP, FMedSci, Professor and Head of Department University College of Clinical Neurosciences, Institute of Neurology, University College London, Queen Square, London UK. Professor of Neurology, National Hospital for Neurology and Neurosurgery and Roayl Free Hospital, London, UK.

Andreas Hartmann, MD, Clinical Investigation Center, Pitie-Salpetriere Hopital, Paris, France. Federation of Nervous System Disease, Pitie-Salpetriere Hopital, Paris, France. National Institute of Health and Medical Research, Paris, France. Pierre and MAric Curie University,?Paris, France.

Yves Agid, MD, PhD, Clinical Investigation Center, Pitie-Salpetriere Hopital, Paris, France. Federation of Nervous System Disease, Pitie-Salpetriere Hopital, Paris, France. National Institute of Health and Medical Research, Paris, France. Pierre and MAric Curie University,?Paris, France.

Table of Contents

Preface

Introduction

What is Parkinson's disease? From pathophysiology to symptoms

Pathophysiology of Parkinson's disease

Dysfunctions of the main neuronal pathways in Parkinson's disease

An overview of neuronal systems affected in Parkinson's disease

Dopaminergic neurons

Non-dopaminergic neurons

Consequences of dopaminergic neuronal lesions on basal ganglia circuits

The dopaminergic nigrostriatal system: pre- and postsynaptic compensatory mechanisms

Pathologic alterations of nigrostriatal circuits in Parkinson's disease

Histopathology of Parkinson's disease

The etiopathogenesis of Parkinson's disease

The genetics of Parkinson's disease: any clues for the sporadic forms?

Relevant environmental factors: focus on mitochondria

Mechanisms of cell death in Parkinson's disease: therapeutic implications

Conclusions

Parkinson's disease or Parkinson's syndromes?

What Parkinson's disease is not

Clinical features of Parkinson's disease

Motor symptoms

Non-motor symptoms

Depression

Apathy

Cognitive impairment

Sleep

Autonomic dysfunction

Sensory symptoms

The different forms of Parkinson's disease: relevance for prognosis

The differential diagnosis of Parkinson's disease

Treatment-related symptoms

Motor complications

Non-motor complications

Treatment of Parkinson's disease

Antiparkinsonian agents

Levodopa

COMT inhibitors

Dopamine agonists

Monoamine oxidase B inhibitors

Other drugs

Medical management

Initiation of treatment

Maintenance of treatment (Fig. 2.7)

Motor complications

Management of non-motor complications

Non-medical management

Surgery

Destructive lesions

Cell therapy

Growth factors

Neuroprotection

MAO-B inhibitors

Dopamine agonists

Coenzyme Q

Creatine

Antiapoptotic drugs

Conclusion

Case studies

Case studies-diagnostic index

Index

Table of Contents provided by Publisher. All Rights Reserved.