Pathology of Bone Marrow

by Naeim, Faramarz

• ISBN13: 9780683303360
• ISBN10: 0683303368
• Edition: 2nd
• Format: Hardcover
• Copyright: 1998-01-01
• Publisher: Williams & Wilkins

Summary

Univ of California, Los Angeles. Comprehensive text and atlas of bone marrow pathology for residents and practitioners. Emphasizes improvement of diagnostic skills. Full-color and halftone micrographs. 3 University of California, Los Angeles contributors. DNLM: Bone Marrow--pathology.

Table of Contents

1. BONE MARROW STRUCTURE AND FUNCTION	1	(36)
Bone Marrow Structure	1	(3)
Hematopoiesis and Regulatory Mechanisms	4	(9)
Hematopoiesis	4	(2)
Hematopoietic Stem Cells	6	(3)
Cytokines	9	(4)
Morphologic Characteristics of Bone Marrow Cells	13	(24)
Neutrophilic Precursors	13	(3)
Basophils and Mast Cells	16	(2)
The Monocyte-Macrophage Lineage	18	(1)
Erythroid Precursors	19	(1)
Platelet Precursors	20	(3)
Lymphocytes and Plasma Cells	23	(4)
Osteoblasts and Osteoclasts	27	(1)
Adipocytes	27	(1)
Fibroblast-Like Cells and Endothelial Cells	28	(9)
2. BONE MARROW EXAMINATION: SPECIAL PROCEDURES	37	(45)
Sample Preparation	37	(3)
Special Stains	40	(6)
Monoclonal Antibodies	46	(18)
DNA Content and Cell Cycle Analysis	64	(2)
DNA Hybridization Techniques	66	(4)
Cytogenetic Analysis	70	(1)
Electron Microscopy	71	(1)
Bone Marrow Culture	72	(10)
3. ABNORMAL MORPHOLOGY: GENERAL CONSIDERATIONS	82	(34)
Abnormal Erythroid Morphology	82	(1)
Abnormal Leukocyte Morphology	83	(6)
Abnormal Bone Marrow Cellularity	89	(1)
Bone Marrow Fibrosis	90	(2)
Granulomas	92	(2)
Bone Marrow Changes in Acquired Immunodeficiency Syndrome	94	(1)
Gelatinous Transformation	94	(5)
Bone Marrow Necrosis	99	(1)
Leukemias and Lymphomas	100	(1)
Bone Marrow Metastasis	100	(7)
Previous Biopsy Site/Repair	107	(1)
Post-Therapeutic Changes	108	(8)
4. CLONAL HEMATOPOIESIS AND EVOLUTION TO HEMATOLOGIC MALIGNANCIES	116	(9)
Oncogenes	116	(4)
Tumor-Suppressor Genes	120	(5)
5. BONE MARROW HYPOPLASIA	125	(15)
Constitutional Aplastic Anemia	125	(1)
Acquired Aplastic Anemia	126	(4)
Paroxysmal Nocturnal Hemoglobinuria	130	(3)
Differential Diagnosis	133	(2)
Therapeutic Approaches	135	(5)
6. MYELODYSPLASTIC SYNDROMES (MDS)	140	(26)
Etiology and Pathogenesis	140	(1)
Pathology	141	(2)
French-American-British (FAB) Classification	143	(9)
Refractory Anemia	146	(1)
Refractory Anemia with Ringed Sideroblasts	146	(1)
Refractory Anemia with Excess Blasts	147	(1)
Chronic Myelomonocytic Leukemia	148	(4)
Refractory Anemia with Excess Blasts in Transformation	152	(1)
Other Subtypes	152	(1)
Other Related Disorders	153	(13)
Therapy-related MDS	153	(1)
Hypocellular MDS	153	(1)
MDS with Fibrosis	154	(1)
Pediatric MDS	154	(1)
Non-Clonal MDS	155	(11)
7. CHRONIC MYELOPROLIFERATIVE DISORDERS	166	(23)
Polycythemia Vera	166	(2)
Essential Thrombocythemia	168	(4)
Myelofibrosis with Myeloid Metaplasia	172	(4)
Chronic Myelogenous Leukemia	176	(4)
Atypical CML	180	(1)
Other Subtypes	180	(9)
8. OTHER DIFFERENTIATED MYELOPROLIFERATIVE DISORDERS	189	(5)
Chronic Neutrophilic Leukemia	189	(1)
Chronic Eosinophilic Leukemia	189	(2)
Chronic Monocytic Leukemia	191	(1)
Basophilic Leukemia	191	(1)
Mast Cell Leukemia	191	(3)
9. ACUTE LEUKEMIAS	194	(61)
Acute Myelogenous Leukemia	194	(3)
FAB Classification	197	(14)
Acute Myeloblastic Leukemia, Minimally Differentiated (AML-MO)	197	(1)
Acute Myeloblastic Leukemia without Maturation (AML-M1)	198	(1)
Acute Myeloblastic Leukemia with Maturation (AML-M2)	198	(1)
Acute Promyelocytic Leukemia (AML-M3)	199	(3)
Acute Myelomonocytic Leukemia (AML-M4)	202	(2)
Acute Monocytic Leukemia (AML-M5)	204	(3)
Erythroleukemia (AML-M6)	207	(3)
Acute Megakaryoblastic Leukemia (AML-M7)	210	(1)
Other Types of Acute Myelogenous Leukemia	211	(9)
Acute Lymphoblastic Leukemia	220	(12)
Morphologic (FAB) Classification	221	(2)
Other Morphologic Variants	223	(2)
Immunologic Classification	225	(7)
Acute Mixed-Lineage Leukemia	232	(3)
AML Expressing Lymphoid-Associated Markers (LY + AML)	233	(1)
ALL Expressing Myeloid-Associated Markers (MY + ALL)	234	(1)
Other Bi- or Multi-Phenotypic Leukemias	234	(1)
Synchronous Acute Bilinear or Biclonal Leukemias	235	(1)
Lineage Switch in Acute Leukemias	235	(1)
Post-Therapeutic Bone Marrow Changes in Patients with Acute Leukemia	235	(2)
Detection of Residual Disease in Acute Leukemia	237	(3)
Relapse	240	(15)
10. CHRONIC LYMPHOID LEUKEMIAS AND RELATED DISORDERS	255	(36)
Chronic Lymphocytic Leukemia	255	(9)
Development of More Aggressive Lymphoid Malignancies in Patients with CLL	262	(2)
Prolymphocytic Leukemia	264	(3)
Hairy Cell Leukemia	267	(6)
Large Granular Lymphocytic Leukemia	273	(2)
HTLV-Associated Leukemia/Lymphoma	275	(3)
Other Types of T-Cell Chronic Lymphoid Leukemia	278	(3)
Sezary Syndrome	278	(3)
S100-Positive T-CLL	281	(1)
Splenic Lymphoma with Villous Lymphocytes	281	(1)
Leukemic Phase of Other Lymphomas	281	(10)
11. MALIGNANT LYMPHOMAS	291	(37)
Hodgkin's Disease	291	(6)
Classification	291	(6)
Non-Hodgkin's Lymphoma	297	(31)
Classification	297	(1)
Low Grade Lymphomas	298	(5)
Other "Mature" B-Cell Lymphomas	303	(1)
Mantle Cell Lymphoma	303	(2)
Marginal Zone B-Cell Lymphoma	305	(2)
Intermediate Grade Lymphomas	307	(1)
High Grade Lymphomas	308	(5)
Other Types of Aggressive Lymphomas	313	(1)
Angioimmunoblastic T-Cell Type	313	(1)
Angiocentric (T/NK) Cell Lymphoma	313	(1)
CD 30+ Anaplastic Large Cell Lymphoma	314	(14)
12. PLASMA CELL DYSCRASIAS	328	(21)
Monoclonal Gammopathy of Undetermined Significance	329	(1)
Multiple Myeloma and Plasmacytoma	330	(7)
IgM Monoclonal Gammopathy	337	(1)
Heavy Chain Disease	337	(3)
Light Chain-Associated Amyloidosis	340	(9)
13. MONOCYTIC AND HISTIOCYTIC DISORDERS	349	(19)
Histiocytosis	349	(1)
Langerhans Cell Histiocytosis	349	(5)
Hemophagocytic Syndromes	354	(4)
Malignant Histiocytosis	358	(1)
Malignant Tumors of Dendritic Cells	359	(1)
Gaucher's Disease	360	(2)
Niemann-Pick Disease	362	(6)
14. GRANULOCYTIC DISORDERS	368	(16)
Chediak-Higashi Syndrome	368	(1)
Chronic Granulomatous Disease	368	(2)
Myeloperoxidase Deficiency	370	(1)
Leukocyte Adhesion Deficiency	370	(1)
Congenital Neutropenia	371	(1)
Cyclic Neutropenia	371	(1)
Autoimmune Neutropenia	371	(3)
Neutrophilia	374	(1)
Hypereosinophilic Syndrome	375	(2)
Mastocytosis	377	(2)
Transient Myeloproliferative Disorder in Down's Syndrome	379	(5)
15. LYMPHOCYTIC DISORDERS	384	(12)
Congenital Immunodeficiency Syndromes	384	(1)
Severe Combined Immunodeficiency	384	(1)
Di George Syndrome	384	(1)
Wiscott-Aldrich Syndrome	384	(1)
Aggamaglobulinema	385	(1)
Acquired Immunodeficiency Syndrome	385	(3)
Idiopathic CD4 + T-lymphocytopenia	388	(1)
Infectious Mononucleosis	389	(1)
X-linked Lymphoproliferative Syndrome	390	(1)
Idiopathic Lymphocytosis	390	(1)
Chronic B-Cell Lymphocytosis	391	(1)
Polyclonal Immunoblastic Proliferations	391	(1)
Bone Marrow Benign Lymphoid Aggregates	391	(5)
16. DISORDERS OF RED BLOOD CELLS	396	(38)
Classification	396	(1)
Disturbance of Proliferation and Differentiation of Erythroid Progenitor Cell	396	(5)
Pure Red Cell aplasia	396	(2)
Congenital Dyserythropoietic Anemia	398	(3)
Megaloblastic Anemia	401	(4)
Iron Deficiency Anemia	405	(2)
Thalassemias	407	(4)
Sickle Cell Diseases	411	(2)
Unstable Hemoglobins	413	(2)
Erythrocyte Membrane Skeleton Defects	415	(3)
Hereditary Spherocytosis	415	(1)
Hereditary Elliptocytosis	415	(2)
Other Membrane-Associated Abnormalities	417	(1)
Hemolytic Anemias Secondary to Erythrocyte Enzyme Abnormalities	418	(2)
Glucose-6-Phosphate Dehydrogenase Deficiency	418	(1)
Pyrovate Kinase Deficiency	418	(2)
Immune Related Hemolytic Anemias	420	(3)
NonImmune Acquired Hemolytic Anemias	423	(2)
Other Types of Anemia	425	(9)
17. DISORDERS OF MEGAKARYOCYTES AND PLATELETS	434	(19)
Megakaryocytosis	434	(1)
Thrombocytopenia	435	(5)
Autoimmune Thrombocytopenic Purpura	436	(1)
Drug-Induced Immune Thrombocytopenia	437	(1)
Neonatal Immune Thrombocytopenia	438	(1)
Post-Transfusion Purpura	438	(1)
Thrombocytopenia in Allergic and Anaphylactic Reactions	439	(1)
Thrombotic Thrombocytopenic Purpura	439	(1)
Other Thrombocytopenias	440	(1)
Qualitative Platelet Disorders	440	(4)
Congenital	441	(3)
Acquired	444	(1)
Platelet Dysfunction Associated with Pathologic Conditions	444	(9)
18. BONE MARROW TRANSPLANTATION	453
Principles of Bone Marrow Transplantation	453	(2)
Aplastic Anemia	455	(1)
Acute Lymphoblastic Leukemia	455	(1)
Acute Myelogenous Leukemia	456	(1)
Chronic Myelogenous Leukemia	457	(1)
Hodgkin's and Non-Hodgkin's Lymphoma	457	(1)
Multiple Myeloma	458	(1)
Thalassemia and Sickle Cell Anemia	458	(1)
Complications of Bone Marrow Transplantation	459	(1)
Morphologic Evaluation of Bone Marrow	459
Before and After Transplantations	459