Peptides

by Hu, Xiao-Yu; Wang, Rui; Tam, James P.

• ISBN13: 9780792362791
• ISBN10: 0792362799
• Format: Hardcover
• Copyright: 2000-10-01
• Publisher: Kluwer Academic Pub

Summary

This book represents the achievements of current peptide science research in China over the last two years. The International Chinese Peptide Symposium is an academic meeting held every two years and this 5th meeting (5th CPS-98) was held on July 14-17 1998, in Lanzhou, Gansu, China, hosted by Lanzhou University. The 5th PCS-98 was represented by over 150 participants including 30 scientists from nine countries outside China. This book contains the keynote lectures and the vast majority of the oral presentations. It covers the highest level of Chinese peptide research and as such should be of great interest to any peptide scientist.

Table of Contents

Preface	v
Chinese Peptide Symposium -- 1998	vii
Session A: Novel approach on synthetic method
Orthogonal ligation of free peptides	3	(5)
J.P. Tam
Y.--A. Lu
Q. Yu
Solid phase synthesis of peptide aldehydes	8	(6)
J.-A. Fehrentz
M. Paris
A. Heitz
M. Rolland
J. Martinez
Investigation of enzyme activity and inhibition in the interior of novel solid supports	14	(7)
M. Meldal
P.M. St. Hilaire
M. Willert
J. Rademann
M. Grotli
J. Buchardt
C.h. Gotfredsen
M.A. Juliano
L. Juliano
K. Bock
Immobilization of α-chymotrypsin on zeolite for peptide synthesis in organic solvent	21	(5)
Y.-H. Ye
G.-W. Xing
G. -L. Tian
C. -X. Li
Preparation of a peptide thioester using a fluoren-9-ylmethoxycarbonyl solid-phase method	26	(4)
X.-Q. Li
T. Kawakami
S. Aimoto
Application of DEPBT for the synthesis of N-protected peptide alcohols	30	(3)
G. -L. Tian
B. -Y. Sun
W. Wang
Y. -H. Ye
Decomposition of amino acid cupric complex by using tetrahydrothiazole-2-thione for preparation of Nα-Boc-Nε-Fmoc-L-Lysine	33	(3)
X. -M. Gao
Y. -H. Ye
G. -L. Tian
D. Wang
Two-step selective formation of three disulfide bridges in the synthesis of δ-Conotoxin P VIA	36	(7)
H. Jiang
C. -X. Fan
Z. -W. Miao
K. -H. Wei
D. -Y. Li
M. -N. Zhong
J. -S. Chen
Session B: Structure, folding and conformation analysis/ De novo design of peptide & protein
Design, synthesis and NMR structure of a rigid cyclic peptide template	43	(5)
S.A. Muhle
J.P. Tam
Automated docking of Sch68631 with HCV NS3 protease	48	(3)
X. -J. Xu
T. -J. Hou
L. -R. Chen
Z. Li
J. -Q. Wang
Molecular modeling of the three-dimensional structure of the human interleukin-11	51	(4)
L. -R. Chen
T. -J Hou
X. -J. Xu
Z. Li
J. -Q. Wang
Designing β-hairpin forming short peptide	55	(4)
Y. -L. Sha
Y. -L. Huang
Q. Wang
L. -H. Lai
Anti-tumor activities of papavor somniferum pollen peptides	59	(3)
J. -X. Xu
S. Jin
Structural investigation of two pollen peptides by 2 D homonuclear NMR spectroscopy	62	(3)
Y. -L. Song
J. -F. Wang
E. -C. Li
Z. -C. Qu
A comparison of three heuristic algorithms for molecular docking	65	(4)
T. -J. Hou
X. -J. Xu
L. -R. Chen
Aggregation of a calmodulin-binding peptide	69	(6)
H. -S. Yan
X. -H. Cheng
A. -G. Ni
B. -L. He
Session C: Neuro/Endocrino/Bioactive peptide
Neuropeptide AVP(4-8) playing an indirect neurotrophic role	75	(2)
Q. -W. Yan
X. -G. Zhen
T. -X. Wang
Y. -C. Du
Potent bradykinin antagonists having medical potential	77	(4)
J. M. Stewart
L. Gera
E. J. York
D. C. Chan
Understanding the chemistry and biology of rodent relaxin: Role of the C-peptide	81	(5)
J. D. Wade
N. F. Dawson
M. Macris
M. Mathieu
Y. -Y. Tan
R. J. Summers
G. W. Tregear
Purification and characterization of a new conotoxin from the venom of Conus betulinu	86	(3)
C. -X. Fan
M. -N. Zhong
H. Jiang
S. -Y. Liu
D. -Y. Li
M. Liu
S. -L. Zhang
F. -S. Lin
J. -S. Chen
Synthesis and biological activity of human calcitonin analogs	89	(3)
C. Yu
D. -F. Cui
G. -M. Zhou
B. -L. Li
X. -F. Wu
Enhanced expression of CNDF mRNA in rat brain by administration of AVP(4-8)	92	(3)
W. -X Li
B. -X Gu
Y. -C Du
The synthesis and opioid activities of nociceptin and its fragments	95	(3)
S. -L. Dong
R. Wang
T. Wang
X. -Y. Hu
The effect of Glu position change on the opioid activity of deltorphin II	98	(4)
R. Wang
D. -J. Yang
Y. -P. Ma
X. -F. Huo
J. -M. Shen
X. -Y. Hu
Isolation and purification of a series of peptides from Panax notoginseng	102	(2)
J. -G. Ji
Y. -H. Ye
Y. -W. Zhou
Q. -Y. Xing
Study of the relationship between structure and function of HIV-1 gp 41 N terminus fusion peptide	104	(4)
M. Wu
S. -Q. Nie
Y. Qiu
K. -C. Lin
S. -X. Wang
S. -F. Sui
Hypotensive activities of nociceptin and its fragments	108	(4)
R. Wang
T. Wang
S. -L. Dong
Q. Chen
X. -Y. Hu
The design and synthesis of endomorphins and their analogues	112	(4)
X. -F. Huo
W. -H. Ren
N. Wu
R. Wang
Neuronal apoptosis induced by β-amyloid peptides in vitro	116	(3)
W. -X. Li
B. -X. Gu
Y. -C. Du
Studies on the spin-labeling technique on deltrophin II and its analogues	119	(5)
D. -J. Yang
R. Wang
Y. -P. Ma
Y. -J. Di
J. -M. Shen
X. -Y. Hu
Design and synthesis of salmon calcitonin and its analogues	124	(2)
H. -P. Pan
L. -Y. Wang
Z. -Y. Chen
F. Wang
H. -X. Wang
Studies on the synthesis and antithrombosis activity of two peptides derived from the molecular-binding site of fibrinogen	126	(3)
X. -Y. Hu
K. -Q. Li
G. -L. Yang
C. -H. Li
Synthesis and expression of ω-conotoxin MVIIA	129	(8)
M. -Y. Cai
X. -M. Qu
Session D: Peptide vaccines/Immunology/Virus
Studies on the synthetic peptide vaccines against schistosomiasis	137	(3)
S. -L. Cao
Z. -H. Qin
M -S. Cai
Y. -E. Shi
Studies on the anti-schistosomal synthetic peptide vaccine: Prediction and synthesis of antigenic peptides of Schistosoma paramyosin	140	(2)
J. -X. Xu
J. -H. Yang
Construction and expression of a recombinant antibody targeted plasminogen activator	142	(3)
J. -S. Yang
P. -C. Jiang
B. -G. Ru
Chemical conjugation between haemophilus influenzae type b (hib) polysaccharide and proteins	145	(2)
P. -S. Lei
G. -S. Lu
Synthesis of human inhibin fragments, preparation and generation of monoclonal antibodies against human inhibin	147	(6)
G. -S. Lu
Y. Sun
P. -S. Lei
X. Huang
H. -M. Xia
X. -D. Gao
Session E: Peptide diversity; Chemical libraries; Ligand-receptor interaction; Peptides in therapeutics & diagnosis
Design of a δ opioid peptide mimetic based on a topographically constained cyclic enkpehalin	153	(5)
V. J. Hruby
S. Liao
M. Shenderovich
J. Alfaro-Lopez
P. Davis
K. Hosohata
F. Porreca
H.I. Yamamura
Tetrazole cis-amide bond mimetics identify the B-turn conformation of insect kinin neuropeptides	158	(5)
R. J. Nachman
J. Zabrocki
V. A. Roberts
G. M. Coast
Synthetic studies of farnesyl protein transferase inhibitor pepticinnamin E	163	(3)
J. -G. Deng
D. -Q. Sun
X. -Q. Lin
A. -Q. Mi
Y. -Z. Jiang
Novel coupling reagents	166	(3)
P. Li
J. -C. Xu
Pharmacophore model of growth hormone secretagogues	169	(3)
L. Liu
R. -X. Wang
L. -H. Lai
C. -X. Li
Discovery that deltorphin II derivatives are potent melanotropins, putatively active at the Xenopus melanocortin-1 receptor	172	(5)
V. J. Hruby
G. Han
M.J. Quillan
W. Sadee
S. Sharma
Session F: Glyco/Lipo/Phospho peptide; peptide diversity/Chemical libraries; Receptor-ligand interaction
Enzymatic synthesis of phosphopeptides	177	(3)
Y. -M. Li
Y. -F. Zhao
H. Waldmann
Synthesis of phosphorylated polypeptide by a thioester method	180	(6)
S. Aimoto
K. Hasegawa
X. -Q. Li
T. Kawakami
Difference between N-phospho-L- and D-Methionine in ester exchange reaction with uridine	186	(2)
Y. Ma
G. -F. Shi
Y. -P. Feng
Y. -F. Zhao
Synthesis of analogs of phosphoamino acids and their biomimic reactions	188	(4)
Y. Ju
D. -Y. Qin
Y. -F. Zhao
Solid phase synthesis of heterocyclic combinatorial libraries derived from peptides	192	(6)
J. M. Ostresh
C. C. Schoner
V. T. Hamashin
M. Giulianotti
A. Nefzi
M. J. Kurth
R. A. Houghten
Parallel synthesis of muramyl peptides derivatives	198	(4)
S. -D. Zhang
G. Liu
S. -Q. Xia
Z. -K. Ding
β-Cyclodextrin for presentation of bioactive peptides to molecular recognition	202	(8)
N. Schaschke
S. Fiori
H. -J. Musiol
I. Assfalg-Machleidt
W. Machleidt
C. Escrieut
D. Fourmy
G. Muller
L. Moroder
The C-terminus of δ-opioid receptor does not control DPDPE-induced desensitization	210	(5)
D. -H. Zhou
C. -H. Wang
Q. Wei
G. Pei
Z. -Q. Chi
Session G: Peptides in therapeutics and diagnosis
Detection of gene expression product of transgenic tobacco by antigenic peptide	215	(2)
J. -X. Xu
Y. Ma
M. Ma
X. -P. Lin
Advantages of Calcitonin complexed with SA liposome	217	(4)
D. Wang
C. Yu
H. -X. Xuan
D. -F. Cui
Q. -S. Lin
Hypoglycemic effects of insulin sublingual drops containing azone on rats and rabbits	221	(6)
H. Peng
Q. -H. Gao
Q. Chen
Y. -S. Zhu
K. -X. Huang
Session H: Other research related to peptides and proteins
Secretory expression of porcine insulin precursor in methylotrophic yeast Pichia pastoris	227	(3)
Y. Wang
Z. -H. Liang
Y. -M. Fent
Y. -S. Zhang
Chemo-enzymatic syntheses of eel calcitonin analogs having natural N-linked oligosaccharides	230	(4)
T. Inazu
M. Mizuno
I. Muramoto
K. Haneda
T. Kawakami
S. Aimoto
K. Yamamoto
Design of specific inhibitors at the ATP binding site of DNA topoisomerases II	234	(4)
L. Assairi
Applications of optical biosensors to structure-function studies in the EGF/EGF receptor system	238	(6)
E.C. Nice
T. Domagala
F. Smyth
N. Konstantopoulos
M. Nerrie
D. Geleick
B. Catimel
A. W. Burgess
Experimental study of osteogenic growth peptide promoting bone mass in rat osteoporosis	244	(3)
D. -Y. Shi
C. Yu
T.-Y. Chen
M.-Y. Li
D.-F. Cui
Z.-W. Chen
Determination of inhibitory constants for CPA by competitive spectrophotometry	247	(2)
N. -J. Hong
J. -W. Lee
S. -H. Chang
D. H. Jin
Sublingual administration of monomeric insulin --destetrapeptide insulin	249	(3)
M. -Y. Li
H. Peng
M. -R. Ai
H. -B. Xu
Y. -X. Zhang
How to get patent rights to protect your invention in biotechnology	252	(3)
L. Zhou
Study of peptide maps from milk protein hydrolysates by SE-HPLC	255	(3)
L. Zhao
Y. Q. Li
Z. -L. Chen
S. -W. She
Y. -F. Wang
Synthesis and solution structures of new chiral enantiomeric peptide nucleic acid (PNA) dimers	258	(4)
L. -G. Zhang
J. -M. Min
L. -H. Zhang
Study of one type of metallothionein and SZ51 recombinant protein directing and imaging reagent	262	(2)
Y. Sun
B. -G. Ru
LHRH antagonists: new preclinical and clinical results	264	(5)
B. Kutscher
M. Bernd
W. Deger
T. Reissmann
R. Deghengi
J. Engel
DNA-binding characteristic of the antitumor drug actinomycin D and its analogs	269	(5)
J. -H. Shen
X. -W. Yang
Z. -P Jia
R. Wang
Design and synthesis of the peptide analogs of antitumor agent actinomycin D	274	(5)
X. -W. Yang
J. -H. Shen
Z. -P. Jia
R. Wang
Author index	279	(4)
Subject index	283