Periodontal Medicine And Systems Biology

by Henderson, Brian; Curtis, Michael; Seymour, Robert; Donos, Nikolaos

• ISBN13: 9781405122191
• ISBN10: 1405122196
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-07-07
• Publisher: Wiley-Blackwell

Summary

This book provides a systems-based approach to periodontology and offers a scientific roadmap of the interactions which can lead to periodontal disease.

Author Biography

Brian Henderson is Professor of Cell Biology in the Division of Microbial Diseases at UCL Eastman Dental Institute, University College London.

Michael A Curtis is Professor of Microbiology and Director of the Institute of Cell and Molecular Science at Barts and The London School of Medicine and Dentistry.

Robert M Seymour is Professor in the UCL Department of Mathematics, University College London.

Professor Nikos Donos is Director of Research Strategy and Head of Periodontology at UCL Eastman Dental Institute, University College London.

Table of Contents

Preface	p. vii
Contributors	p. ix
Systems Theory and Cooperative Bacteria
Systems thinking in biology	p. 3
Metagenomics and its applications to human bacterial diseases	p. 21
Periodontitis: The Clinical Disease
Periodontitis: a modern clinical picture	p. 33
Plaque microbiology in (periodontal) health and disease	p. 59
Population molecular genetics of periodontitis	p. 77
Mechanisms linking periodontitis to systemic disease	p. 97
The impact of diabetes-enhanced inflammation on periodontal disease and bone destruction	p. 117
Periodontitis: Coping with The Microbiota
The microbiota of humans	p. 129
The normal oral microbiota	p. 139
Bacterial coaggregation and periodontitis	p. 151
Dynamics of biofilm formation and relationship to periodontitis	p. 165
Quorum sensing as a means of biofilm communication	p. 177
Genomics of Porphyromonas gingivalis	p. 193
Genomics of Fusobacterium nucleatum	p. 205
The Aggregatibacter (formerly Actinobacillus) actinomycetemcomitans genomeannotation, analysis and metabolic reconstruction	p. 219
Periodontitis: Innate and Acquired Immunity
A new view of innate immunity for the twenty-first century	p. 247
Innate immunity and homeostasis in the periodontium	p. 263
Antimicrobial host defence peptides in oral health and periodontitis	p. 279
Control of inflammation in periodontal disease	p. 299
Antigen-presenting cells in chronic periodontitis	p. 317
B-cell responses in periodontitis	p. 339
T-cell responses in periodontitis	p. 357
Periodontitis: Bone Destruction
Current paradigms of osteoblast-osteoclast interactions and bacterial pathogen-induced bone resorption	p. 379
Bacterial osteolytic mediators	p. 395
Immune cell involvement in periodontal bone loss	p. 407
How can periodontal bone loss be stopped?	p. 427
Index	p. 439
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