Peripheral Benzodiazepine Receptors

by Giesen-Crouse; Jenner

• ISBN13: 9780122826306
• ISBN10: 0122826302
• Format: Hardcover
• Copyright: 1993-05-05
• Publisher: Elsevier Science

Summary

Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. Although peripheral type benzodiazepne recognition sites have been demonstrated in the brain and peripheral organs of various species for more than 10 years, the exact physiological function or pharmacological effects have not yet been established. Peripheral benzodiazepine literature is so overwhelming that the novice may find it virtually impossible to form a clear idea about the diverse findings. This volume, dedicated exclusively to pBR and their natural and synthetic ligands, puts the available data into perspective. A truly interdisciplinary approach has brought neuroscientists, cardiologists, endocrinologists, and immunologists together to work on the description of pBR-mediated effects. The chemistry, biochemistry, and molecular biology of the pBR receptor and its ligands are reviewed, their pharmacological usefulness is conjectured, and thus a true overview of the field is provided. * SPECIAL FEATURES * This volume follows the Neuroscience Perspectives brief of providing a historical background, pharmacological, biochemical and physiological aspects of research and therapeutic potential, of its chosen topic. * The peripheral benzodiazepine recognition site has been recognised for more than ten years, but the exact physiological and pharmacological effects have not yet been established.

Table of Contents

Biochemical and Chemical Characteristics of the Mitochondrial Benzodiazepine Receptor and Its Ligands

Biochemical and Molecular Properties of Mitochondrial Benzodiazepine Receptors

Binding Characteristics of the Receptor and Coupling to Transport Protein(S)

Endogenous and Synthetic Ligands of the Receptor: Structure-Affinity Relationships

Pharmacological Effects of Peripherally Acting Benzodiazepines

The Role of the Mitochondrial Benzodiazepine Receptors in Steroidogenesis

Effects on Cell Growth and Differentiation

Immunostimulating Effects of Peripherally Acting Benzodiazepines

Central and Peripheral Type Benzodiazepine Receptors: Role in Memory Regulation and Possible Relation to Anxiety Levels

Mitochondrial Benzodiazepine Receptors and Smooth Muscle Reactivity

Cardiovascular Actions of Peripheral Acting Benzodiazepines

Modulation of Receptor Numbers in Response to Pathophysiological Situations

Effects of Change in Tissue Concentrations of Putative Endogenous Ligands on Mitochondrial Benzodiazepine Receptors Ex Vivo

Modification of Receptor Numbers in Stressful Situations

Pathophysiological and Endocrinological Aspects of Mitochondrial Benzodiazepine Receptor Densities

Mitochondrial Benzodiazepine Receptor Ligands as Indicators of Damage to the CNS: Their Application in Positron Emission Tomography

Subject Index

Table of Contents provided by Publisher. All Rights Reserved.