The Peripheral T-Cell Lymphomas

by O'Connor, Owen A.; Kim, Won Seog; Zinzani, Pier L.

• ISBN13: 9781119671312
• ISBN10: 1119671310
• Edition: 1st
• Format: Hardcover
• Copyright: 2021-06-01
• Publisher: Wiley-Blackwell

Summary

THE PERIPHERAL T-CELL LYMPHOMAS

Provides a comprehensive look at Peripheral T-Cell lymphomas, including the group’s unique geographic distribution, underlying genetics, and novel treatments

Peripheral T-Cell lymphomas (PTCL) are a diverse group of lymphoid malignancies that develop from mature T cells and natural killer (NK) cells. PTCL represent 10-15% of all cases of non-Hodgkin lymphoma in the US, and up to 20-25% of cases in South America, Asia, and other regions around the world. The role of different etiologic factors and the variation of geographic distribution makes PTCL one of the most difficult types of cancer to understand and treat.

For the first time in a single volume, The Peripheral T-Cell Lymphomas presents a comprehensive survey of this complex and rare group of blood cancers. Featuring contributions from an international team of leading authorities in the various aspects of PTCL, this authoritative text covers biology, epidemiology, classification, approved and emerging drugs, molecular genetics, and more. Detailed clinical chapters address diagnosis, prognosis, and treatment of each of the major PTCL subtypes identified in the 2018 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. This much-needed resource:

• Covers the biological basis, epidemiology, classification, and treatment of PTCL
• Discusses the future of the field, including global collaboration efforts and novel approaches to PCTL
• Explores the role of biologics in PTCL and autologous and allogeneic stem-cell transplantation
• Offers new insights on molecular pathogenesis, innovative therapeutics, and novel drug combinations
• Features contributions from the Chairs The T-Cell Lymphoma Forum: the world’s largest meeting focused on PTCL

Reflecting the unique epidemiology and genetic diversity of the PTCL, The Peripheral T-Cell Lymphomas is an indispensable source of data, insight, and references for the medical community, particularly oncologists and hematologists in both training and practice.

Author Biography

Owen A. O’Connor, MD, PhD is American Cancer Society Research Professor, Professor of Medicine and Experimental Therapeutics, and Founding Director of the Center for Lymphoid Malignancies, Columbia University Medical Center, New York, NY, USA. 

Won Seog Kim, MD, PhD is Professor of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.  

Pier Luigi Zinzani, MD, PhD is Professor of Hematology, Director of Lymphoma and CLL Unit, and Chief of Phase I clinical trials, Institute of Hematology, University of Bologna, Bologna, Italy. 

Table of Contents

List of contributors to be generated by the copy editor

Part 1: Biological Basis of the Peripheral T-Cell Lymphomas

1 Fundamentals T-Cell Lymphocyte Biology

Claudio Tripodo, Stefano Pilleri

2 Mechanisms of T-cell Lymphomagenesis

François Lemonnier, Philippe Gaulard, Laurence de Leval

3 Epigenetics of T-cell Lymphoma

H. Miles Prince, Jasmine Zain, Anas Younes, Sean Whittaker, Owen O’Connor, Sean Harrop

4 Animal Models of T-cell Lymphoma

Keiichiro Hattori, Raksha Shrestha, Tatsuhiro Sakamoto, Manabu Kusakabe, Mamiko Sakata-Yanagimoto

Part 2: Epidemiology and Classification of the PTCL

5 The Geographic Distribution of the PTCL: Global Epidemiology

Amulya Yellala, Avyakta Kallam, James Armitage

6 Classification of the Peripheral T-Cell Lymphomas

Neval Ozkaya, Elaine Jaffee

7 Molecular Classification of the PTCLs

Tyler A. Herek, Javed Iqbal

Part 3: Discrete Clinical Subtypes of PTCL (Unique Epidemiology, Therapy and Management)

8 Peripheral T-Cell Lymphoma – Not Otherwise Specified

Nora Bennani, Stephen Ansell

9 Angioimmunoblastic T-cell Lymphoma (AITL)

Jehan Dupuis, Franck Morschhauser

10 The Spectrum of Anaplastic Large Cell Lymphoma

Jianping Kong, Andrew Feldman

11 HTLV-1-Positive Adult T-Cell Leukemia-Lymphoma (ATL)

Wataru Munakata, Kensei Tobinai

12 Natural Killer/T Cell Lymphomas

S.J. Kim, R. Suzuki, A. Jaccard, S.T. Lim, Won Seog Kim

13 T-Prolymphocytic Leukemia (T-PLL)

Dima El-Sharkawi, Claire Deardon

14 Large Granular Lymphocytes Leukemia (LGL)

Karolina H. Dziewulska, Katharine B. Moosic, HeeJin Cheon, Kristine C. Olson, David J. Feith, Thomas P. Loughran, Jr.

15 Gamma Delta T-cell Lymphomas

Francine Foss, Aadil Ahmed, Mina Xu

16 Enteropathy Associated T-Cell Lymphoma and Monomorphic Epitheliotropic Intestinal T-cell lymphoma

Craig R. Soderquist, Jennifer Shingleton, Sandeep Dave, Govind Bhagat

17 Hepatosplenic T-Cell Lymphomas

Robert N. Stuver, Mwanasha Merrill, Salvia Jain

18 Cutaneous T-Cell Lymphoma

Alejandro Ariel Gru, Bethanie Rooke, Kevin Molloy, Julia Scarsbrick

19 Other Rare Subtypes of PTCL

Pier Paolo Picaluga

Part 4: Treatment of the PTCL

20 Standard Front-line Therapies

Raphael Koch, Lorenz Truemper

21 Approved Agents in the Relapsed or Refractory Setting, Excluding Brentuximab vedotin

Helen Ma, Owen A. O’Connor

22 The Role for Autologous Stem Cell Transplantation (ASCT) in Peripheral T Cell Lymphomas (PTCL)

Juan Alejandro Ospina, H. Martinez-Cordero, J. Enciso, H. Idrobo

23 Allogeneic Stem Cell Transplantion

Anna Dodero, Paolo Corradini

24 Emerging Immunotherapy Approaches in Peripheral T-Cell Lymphomas

Barbara Pro, Andrei Shustov

25 Emerging New Small Molecules in Peripheral T-Cell Lymphomas

Alessandro Broccoli, Pier Luigi Zinzani

Part 5: Future Directions

26 The Value and Relevance of T-cell Lymphoma Registries

Tetiana Skrypets, Martina Manni, Monica Civallero, Iryna Kriachok, Massimo Federico

27 Innovative Chemotherapy-Free Approaches for the Treatment of PTCL 

Enrica Marchi, Ahmed Sawas, Helen Ma, Luigi Scotto, Francesca Montanari

28 Global Collaborations

Dejan Radjeski, Eliza Hawke, Owen A. O’Connor, Pier Luigi Zinzani, WonSeog Kim, Enrica Marchi